Chromatin mainly consists of protein and DNA, and the sequence information of DNA contributes to controlling the spatial structure of chromatin. Genome-wide contact patterns of chromosome at high precision uncover fine structural properties, conductive to exploring underlying mechanisms on structure establishment and function realization for chromatin. In this short review, we describe changes of chromatin structure during various biological processes from a DNA sequence view, with an increase of the overall domain segregation from birth to senescence and establishment of cell identity related cross-domain contacts. Segregation patterns vary with cell stage and genomic distance. Meanwhile, possible effects of cell cycle, temperature, nuclear lamina and nucleolus on chromatin structure are discussed. At last, important roles of transcription factors and other proteins in proper chromatin organization are also discussed.

中文翻译：

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从DNA序列的角度来看，染色质结构在各种过程中都会发生变化。

染色质主要由蛋白质和DNA组成，DNA的序列信息有助于控制染色质的空间结构。染色体的全基因组高精度接触模式揭示了精细的结构特性，有助于探索染色质结构建立和功能实现的潜在机制。在这篇简短的综述中，我们从DNA序列的角度描述了各种生物学过程中染色质结构的变化，从出生到衰老的整体结构域分离的增加以及与细胞身份相关的跨结构域接触的建立。分离模式随细胞阶段和基因组距离而变化。同时，讨论了细胞周期，温度，核纤层和核仁对染色质结构的可能影响。终于，