Plant shoot apical meristems (SAMs) play essential roles in plant growth and development. Located at the growing tip of a plant stem, these dome-like structures contain stem cells, which serve to perpetuate themselves in an undifferentiated state while continually adding new cells that differentiate and eventually form all above-ground tissues. In a SAM, the pool of stem cells is dynamically maintained through a balance between cell division (self-renewal) and differentiation (loss of stem-cell identity). In the model plant Arabidopsis thaliana, a negative feedback loop between WUSCHEL (WUS) and the CLAVATA3 (CLV3) plays important roles in maintaining the stem cell population. In this review, we highlight recent findings mainly from studies in Arabidopsis, and summarize the research progress on understanding how multiple transcriptional circuits integrate and function at different cell layers to control the WUS-CLV3 loop and stem cell homeostasis.

中文翻译：

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转录回路控制芽干细胞稳态。

植物茎尖分生组织（SAMs）在植物生长和发育中起重要作用。这些圆顶状结构位于植物茎的生长尖端，包含干细胞，这些干细胞用于在未分化状态下永存，同时不断添加分化并最终形成所有地上组织的新细胞。在SAM中，通过细胞分裂（自我更新）和分化（失去干细胞身份）之间的平衡来动态维护干细胞库。在模型植物拟南芥中，WUSCHEL（WUS）和CLAVATA3（CLV3）之间的负反馈回路在维持干细胞种群中起重要作用。在这篇评论中，我们重点介绍了来自拟南芥研究的最新发现，