This systematic review aims to summarize epigenome-wide studies on aberrant DNA methylation and its association with survival in patients with gastrointestinal adenocarcinoma. The 15 studies identified showed a large variety of methodological approaches for the identification of prognostic epigenetic markers from genome-wide methylation analyses. None of the findings were reported by more than one study in this systematic review. Further validation studies, a better reporting of methods and results are needed, as well as a clearer definition of investigated outcomes. At present, no conclusions can be drawn on the clinical relevance of the reported epigenetic markers.

中文翻译：

---

胃肠道腺癌患者预后DNA甲基化生物标志物的鉴定：表观基因组研究的系统评价。

本系统综述旨在总结表观基因组范围的胃肠道腺癌患者异常DNA甲基化及其与生存的关系的研究。鉴定的15项研究显示了从全基因组甲基化分析中鉴定预后表观遗传标记的多种方法学方法。在这项系统评价中，一项以上的研究均未报告任何发现。需要进行进一步的验证研究，需要对方法和结果进行更好的报告，并且需要对研究结果进行更清晰的定义。目前，尚无关于报道的表观遗传标记的临床相关性的结论。