Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass,Green Chemistry

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Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass
Green Chemistry ( IF 9.3 ) Pub Date : 2019-11-25 , DOI: 10.1039/c9gc02359c
Robson Tramontina _{1,

2,

3,

4,

5} , James L. Galman _{1,

2,

3,

4,

5} , Fabio Parmeggiani _{1,

2,

3,

4,

5} , Sasha R. Derrington _{1,

2,

3,

4,

5} , Timothy D. H. Bugg _{5,

6,

7,

8} , Nicholas J. Turner _{1,

2,

3,

4,

5} , Fabio M. Squina _{9,

10,

11,

12} , Neil Dixon _{1,

2,

3,

4,

5}

Affiliation

Sustainable production of fine chemicals and biofuels from renewable biomass offers a potential alternative to the continued use of finite geological oil reserves. However, in order to compete with current petrochemical refinery processes, alternative biorefinery processes must overcome significant costs and productivity barriers. Herein, we demonstrate the biocatalytic production of the versatile chemical building block, coniferol, for the first time, directly from lignocellulosic biomass. Following the biocatalytic treatment of lignocellulose to release and convert ferulic acid with feruloyl esterase (XynZ), carboxylic acid reductase (CAR) and aldo-keto reductase (AKR), this whole cell catalytic cascade not only achieved equivalent release of ferulic acid from lignocellulose compared to alkaline hydrolysis, but also displayed efficient conversion of ferulic acid to coniferol. This system represents a consolidated biodegradation–biotransformation strategy for the production of high value fine chemicals from waste plant biomass, offering the potential to minimize environmental waste and add value to agro-industrial residues.

中文翻译：

直接从木质纤维素生物质中综合生产松柏油和其他高价值的芳族醇

由可再生生物质可持续生产精细化学品和生物燃料，为继续使用有限的地质石油储备提供了潜在的替代方法。然而，为了与当前的石化精炼工艺竞争，替代性的生物精炼工艺必须克服显着的成本和生产率障碍。在本文中，我们首次展示了直接从木质纤维素生物质中直接生物催化生产多功能化学构建基松柏油的方法。经过木质素纤维素的生物催化处理，以阿魏酸酯酶（XynZ），羧酸还原酶（CAR）和醛酮还原酶（AKR）释放和转化阿魏酸后，相比于木质纤维素，这种全细胞催化级联不仅实现了阿魏酸的同等释放碱水解而且还显示出阿魏酸向松柏油的有效转化。该系统代表了一种综合的生物降解-生物转化战略，可用于从废物植物生物质中生产高价值的精细化学品，具有将环境废物减至最少并为农业工业残留物增加价值的潜力。

更新日期：2019-11-25

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