Findings from a large, international study comprising 4.9 million people with mild hypertension suggest that thiazide and thiazide-like diuretics might be more effective and safer than other first-line antihypertensive drugs. However, the study was not randomized, and the findings might be explained by a phenomenon known as ‘confounding by indication’.

中文翻译：

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评估高血压疗法：随机分配还是因适应症而混淆？

一项涉及490万人的轻度高血压的大型国际研究发现，噻嗪类和噻嗪类利尿剂可能比其他一线抗高血压药更有效，更安全。但是，该研究不是随机的，其发现可能由一种被称为“适应症混淆”的现象来解释。