Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in neuroscience research studies for interrogating cellular and neurocircuit functions and mapping brain connectivity. Clinically, AAVs are showing increasing promise as viable candidates for treating multiple neurological diseases. Here, we briefly review the utility of AAVs in mapping neurocircuits, manipulating neuronal function and gene expression, and activity labeling in preclinical research studies as well as AAV-based gene therapies for diseases of the nervous system. This review highlights the vast potential that AAVs have for transformative research and therapeutics in the neurosciences.

中文翻译：

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神经科学研究中的腺相关病毒载体。

腺相关病毒载体（AAV）在神经科学研究中越来越有用的临床前工具，用于询问细胞和神经回路功能并绘制大脑连通性。在临床上，AAVs作为治疗多种神经系统疾病的可行候选物显示出越来越高的希望。在这里，我们简要回顾了AAV在神经回路定位，操纵神经元功能和基因表达以及临床前研究以及针对神经系统疾病的基于AAV的基因治疗中的活性标记中的实用性。这篇评论强调了AAV在神经科学领域的变革性研究和治疗方法的巨大潜力。