Neuropathic Pain (NPP) is caused by direct or indirect damage to the nervous system and is a common symptom of many diseases. Clinically, drugs are usually used to suppress pain, such as (lidocaine, morphine, etc.), but the effect is short-lived, poor analgesia, and there are certain dependence and side effects. Therefore, the investigation of the treatment of NPP has become an urgent problem in medical, attracting a lot of research attention. P2X7 is dependent on Adenosine triphosphate (ATP) ion channel receptors and has dual functions for the development of nerve damage and pain. In this review, we explored the link between the P2X7 receptor (P2X7R) and NPP, providing insight into the P2X7R and NPP, discussing the pathological mechanism of P2 X7R in NPP and the biological characteristics of P2X7R antagonist inhibiting its over-expression for the targeted therapy of NPP.

中文翻译：

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P2X7受体在神经性疼痛中的作用和药理特性。

神经性疼痛（NPP）是由直接或间接损害神经系统引起的，是许多疾病的常见症状。临床上，通常使用药物来抑制疼痛，例如（利多卡因，吗啡等），但这种作用是短暂的，镇痛效果差，并且有一定的依赖性和副作用。因此，对NPP的治疗方法的研究已成为医学上的紧迫问题，引起了很多研究的关注。P2X7依赖于三磷酸腺苷（ATP）离子通道受体，对神经损伤和疼痛的发展具有双重作用。在这篇评论中，我们探讨了P2X7受体（P2X7R）与NPP之间的联系，从而深入了解了P2X7R和NPP，