Induced pluripotent stem cells (iPSCs) can be used to generate different types of somatic cells in vitro, including neuronal cells. Here, a human iPSC line was generated from the peripheral blood mononuclear cells of a healthy 39-year-old individual. The resulting iPSCs were integration-free, maintained the normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. Furthermore, we showed that this iPSC line could be differentiated into neural stem cells. Taken together, this generated iPSC line could be useful to test multiple differentiation protocols, and also serve as a control for investigating drug development and disease mechanisms.

诱导多能干细胞（iPSC）可用于体外产生不同类型的体细胞，包括神经元细胞。在此，从健康的39岁个体的外周血单核细胞生成了人iPSC系。产生的iPSC不受整合，保持正常的核型，表达多能干细胞标记，并被证明能够分化为代表三个胚芽层的细胞。此外，我们表明该iPSC系可以分化为神经干细胞。综上所述，这种产生的iPSC品系可用于测试多种分化方案，也可作为研究药物开发和疾病机制的对照。