Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner. To explain that, Roca and colleagues describe an inter-orgallenar circuit which involves the lysosomal ceramide production, mitoROS, BAX activation and RyR Ca2+ efflux from the endoplasmic reticulum into the mitochondrion.

中文翻译：

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钙和活性氧：两位乐团总监为死者安葬。

肿瘤坏死因子α（TNF）通过线粒体活性氧（mitoROS）产生以RIPK1 / 3依赖性方式触发分枝杆菌感染的巨噬细胞的调节性坏死。为了解释这一点，Roca等人描述了一个组织间神经节回路，该回路涉及溶酶体神经酰胺的产生，mitoROS，BAX活化和RyR Ca2 +从内质网进入线粒体。