Sonodynamic therapy (SDT) shows tremendous potential to induce immunogenic cell death (ICD) and activate antitumor immunity. However, it can aggravate hypoxia and release platelet (PLT)-associated danger-associated molecular patterns (DAMPs), which impede therapeutic efficacy and promote tumor metastasis. In order to solve these problems, a biomimetic decoy (designated as Lipo-Ce6/TPZ@MH ) is constructed to reverse the drawbacks of SDT by loading sonosensitizer chlorin e6 (Ce6) and hypoxia-activated tirapazamine (TPZ) in the red blood cells-PLTs hybrid membrane (MH )-camouflaged pH-sensitive liposome. After administration, the decoy exhibits enhanced cancer accumulation and retention abilities due to the immune escape and specific targeting behaviors by biomimetic surface coating. Upon local ultrasound, Ce6 produces toxic reactive oxygen species for SDT, and the resulting hypoxia microenvironment activates TPZ, which can realize a high-effective synergistic therapy. Meanwhile, DAMPs-mediated tumor metastasis is significantly inhibited, because the decoy retains platelet binding functions but is incapable of platelet-mediated metastasis. In addition, ICD-mediated strong antitumor immunities further prevent the growth and metastasis of the residual tumors left behind after synergistic treatment. Taken together, this study highlights the potential of using this cascade therapeutic therapy plus biomemitic decoy in one nanosystem to both eliminate melanoma in situ and suppress lung metastasis.

中文翻译：

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仿生诱饵通过逆转声动力疗法的弊端来抑制肿瘤的生长和肺转移。

声动力疗法（SDT）显示出巨大的潜力来诱导免疫原性细胞死亡（ICD）和激活抗肿瘤免疫力。但是，它会加重缺氧并释放血小板（PLT）相关的危险相关分子模式（DAMPs），从而阻碍治疗效果并促进肿瘤转移。为了解决这些问题，构建了仿生诱饵（命名为Lipo-Ce6 / TPZ @ MH）以通过在红细胞中加载声敏剂二氢卟酚e6（Ce6）和缺氧激活的替拉帕明（TPZ）来逆转SDT的缺点。 -PLTs杂合膜（MH）伪装的pH敏感脂质体。给药后，由于仿生表面涂层的免疫逃逸和特定的靶向行为，诱饵显示出增强的癌症蓄积和保留能力。进行局部超声检查后，Ce6会产生用于SDT的有毒活性氧，并且所产生的缺氧微环境会激活TPZ，从而可以实现高效的协同治疗。同时，DAMPs介导的肿瘤转移被显着抑制，因为诱饵保留了血小板结合功能，但无法进行血小板介导的转移。此外，ICD介导的强抗肿瘤免疫力进一步防止了协同治疗后残留的残留肿瘤的生长和转移。综上所述，这项研究强调了在一个纳米系统中使用这种级联治疗疗法和生物通透诱饵来消除原位黑色素瘤和抑制肺转移的潜力。DAMPs介导的肿瘤转移被显着抑制，因为诱饵保留了血小板结合功能，但无法进行血小板介导的转移。此外，ICD介导的强抗肿瘤免疫力进一步防止了协同治疗后残留的残留肿瘤的生长和转移。综上所述，这项研究强调了在一个纳米系统中使用这种级联治疗疗法和生物通透诱饵来消除原位黑色素瘤和抑制肺转移的潜力。DAMPs介导的肿瘤转移被显着抑制，因为诱饵保留了血小板结合功能，但无法进行血小板介导的转移。此外，ICD介导的强抗肿瘤免疫力进一步防止了协同治疗后残留的残留肿瘤的生长和转移。综上所述，这项研究强调了在一个纳米系统中使用这种级联治疗疗法和生物通透诱饵来消除原位黑色素瘤和抑制肺转移的潜力。