Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects.,Advanced Healthcare Materials

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Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-11-25 , DOI: 10.1002/adhm.201901301
Chen Hu _{1,

2} , Lin-Lin Wang ₃ , Yu-Qing Lin _{1,

2} , Hui-Min Liang _{1,

2} , Shan-Yu Zhou ₄ , Fen Zheng _{5,

6} , Xiao-Li Feng _{1,

2} , Yong-Yu Rui ₅ , Long-Quan Shao _{1,

2}

Affiliation

Due to their excellent size, designability, and outstanding targeted antibacterial effects, nanoparticles have become a potential option for controlling oral biofilm-related infections. However, the formation of an oral biofilm is a dynamic process, and factors affecting the performance of antibiofilm treatments are complex. As such, when examining the existing literature on the antibiofilm effects of nanoparticles, attention should be paid to the specific mechanisms of action at different stages of oral biofilm formation, as well as relevant influencing factors, in order to achieve an objective and comprehensive evaluation. This review is intended to detail the antibacterial mechanisms of nanoparticles during the four stages of the formation of oral biofilms: 1) acquired film formation; 2) bacterial adhesion; 3) early biofilm development; and 4) biofilm maturation. In addition, factors influencing the antibiofilm properties of nanoparticles are summarized from the aspects of nanoparticles themselves, biofilm models, and host factors. The limitations of current research and possible trends for future research are also discussed. In summary, nanoparticles are a promising antioral biofilm strategy. It is hoped that this review can serve as a reference and inspire ideas for further research on the application of nanoparticles for effectively targeting and treating oral biofilms.

中文翻译：

纳米粒子治疗口腔生物膜：现状，机理，影响因素和前景。

由于其出色的尺寸，可设计性和出色的靶向抗菌效果，纳米颗粒已成为控制口腔生物膜相关感染的潜在选择。但是，口腔生物膜的形成是一个动态过程，影响抗生物膜治疗性能的因素很复杂。因此，在审查有关纳米颗粒的抗生物膜作用的现有文献时，应注意在口腔生物膜形成的不同阶段的特定作用机理以及相关的影响因素，以实现客观而全面的评估。这篇综述旨在详细介绍纳米颗粒在口腔生物膜形成的四个阶段的抗菌机理：1）获得性膜形成；2）细菌粘附；3）生物膜的早期发育；4）生物膜成熟。另外，从纳米颗粒本身，生物膜模型和宿主因子的方面总结了影响纳米颗粒的抗生物膜特性的因素。还讨论了当前研究的局限性和未来研究的可能趋势。总之，纳米颗粒是一种有前途的抗口腔生物膜策略。希望这篇综述可以作为参考，并为进一步研究纳米颗粒在有效靶向和治疗口腔生物膜中的应用启发思想。纳米粒子是一种有前途的抗口腔生物膜策略。希望这篇综述可以作为参考，并为进一步研究纳米颗粒在有效靶向和治疗口腔生物膜中的应用启发思想。纳米粒子是一种有前途的抗口腔生物膜策略。希望这篇综述可以作为参考，并为进一步研究纳米颗粒在有效靶向和治疗口腔生物膜中的应用启发思想。

更新日期：2019-12-19

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