Magnetic resonance imaging and spectroscopy are versatile methods for probing brain physiology, but their intrinsically low sensitivity limits the achievable spatial and temporal resolution. Here, we introduce a monolithically integrated NMR-on-a-chip needle that combines an ultra-sensitive 300 µm NMR coil with a complete NMR transceiver, enabling in vivo measurements of blood oxygenation and flow in nanoliter volumes at a sampling rate of 200 Hz.

中文翻译：

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用于以高空间和时间分辨率探测大脑生理的 CMOS 核磁共振针。

磁共振成像和光谱学是探测大脑生理学的通用方法，但其固有的低灵敏度限制了可实现的空间和时间分辨率。在这里，我们介绍了一种单片集成 NMR-on-a-chip 针，它结合了超灵敏的 300 µm NMR 线圈和完整的 NMR 收发器，能够以 200 Hz 的采样率对纳升体积的血氧和流量进行体内测量.