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1,1-Bis(dimethylamino)-2,2-difluoroethene, a diverse building block for the preparation of difluoroalkyl molecules. Acylation and condensation reactions
Journal of Fluorine Chemistry ( IF 1.7 ) Pub Date : 2019-11-23 , DOI: 10.1016/j.jfluchem.2019.109432
Yuelian Xu , Simon E. Lopez , William R. Dolbier

1,1-Bis(dimethylamino)-2,2-difluoroethene has been shown to be a diverse and highly effective building block for the preparation of a variety of fluorinated compounds. Reported here are preliminary results of its use for acylation reactions with acyl chlorides to form 2,2-difluoroketoacetamides as well as for its direct condensation with various acidic α-hydrogen carbon compounds to form a variety of functionalized difluoromethyl enamines.



中文翻译:

1,1-双(二甲基氨基)-2,2-二氟乙烯,一种用于制备二氟烷基分子的多样化结构单元。酰化和缩合反应

1,1-双(二甲基氨基)-2,2-二氟乙烯已被证明是用于制备多种氟化化合物的多样且高效的构件。本文报道了其用于与酰氯进行酰化反应以形成2,2-二氟酮乙酰胺以及与各种酸性α-氢碳化合物直接缩合以形成各种官能化的二氟甲基烯胺的初步结果。

更新日期:2019-11-26
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