Nine undescribed triterpenoids (jughopenoids A-I), including seven nortriterpenoids and two normal triterpenoids, together with fourteen known analogues, were isolated from the barks of Juglans hopeiensis Hu. The structures of the undescribed triterpenoids were established by integrated spectroscopic analysis and single crystal X-ray diffraction. Jughopenoid A represented an unprecedented lupane-type nortriterpenoid with a five-membered lactone ring A. Selected isolates were tested for their cytotoxic effects against human HT-29 colon carcinoma, human HepG2 hepatocellular carcinoma, and human PC-3 prostate cancer cell lines. Their immunosuppressive activities against ConA-induced T cell proliferation and LPS-induced B cell proliferation were also evaluated.

中文翻译：

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胡桃树皮中的三萜类化合物

从胡桃树的树皮中分离出九种未描述的三萜 (jughopenoids AI)，包括七种去甲三萜和两种正常三萜，以及十四种已知的类似物。通过综合光谱分析和单晶 X 射线衍射确定了未描述的三萜类化合物的结构。Jughopenoid A 代表了一种前所未有的具有五元内酯环 A 的羽扇豆型去甲三萜。测试了选定的分离株对人 HT-29 结肠癌、人 HepG2 肝细胞癌和人 PC-3 前列腺癌细胞系的细胞毒性作用。还评估了它们对 ConA 诱导的 T 细胞增殖和 LPS 诱导的 B 细胞增殖的免疫抑制活性。