Improved endovascular embolization can contribute to assistant treatment for patients. However, many traditional embolic materials, such as metal microcoils or liquid embolic agents, are associated with limitations of coil migration or recanalization. Herein, as the first trial, an injectable and radiopaque liquid metal/calcium alginate (LM/CA) hydrogel is introduced and fabricated as a candidate for endovascular embolization and tumor embolotherapy through developing LM droplets as radiopaque units into biocompatible calcium alginate cross-linked network. The adoption of LM droplets makes hydrogels radiopaque under X-ray and CT scan, which significantly facilitates the tracking of material location during surgical vascular operation. In addition, in vitro and in vivo experiments prove that such smart hydrogel could convert from liquid to solid rapidly via cross-linking, showing pretty flexible and controllable functions. Benefiting from these properties, the hydrogel can be performed in blood vessels through injection via syringes and then served as an embolic material for endovascular embolization procedures. In vivo experiments demonstrate that such hydrogels can occlude arteries and block blood flow until they ultimately lead to ischemic necrosis of tumors and partial healthy tissues. Overall, the present LM/CA hydrogels are promising to be developed as new generation embolic materials for future tumor embolotherapy.

中文翻译：

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可注射和不透射线的液态金属/藻酸钙水凝胶，用于血管内栓塞和肿瘤栓塞治疗。

改善的血管内栓塞可以为患者提供辅助治疗。但是，许多传统的栓塞材料（例如金属微线圈或液体栓塞剂）与线圈迁移或再通的局限性有关。在本文中，作为第一个试验，通过将LM液滴作为不透射线的单元发展为生物相容性海藻酸钙交联网络，引入并制造了可注射且不透射线的液态金属/海藻酸钙（LM / CA）水凝胶，并将其制成血管内栓塞和肿瘤栓塞治疗的候选药物。 。LM液滴的采用使水凝胶在X射线和CT扫描下不透射线，这极大地促进了在手术血管手术过程中追踪材料的位置。此外，体外和体内实验证明，这种智能水凝胶可以通过交联从液体迅速转化为固体，显示出相当灵活和可控的功能。得益于这些特性，水凝胶可通过通过注射器注射在血管中进行，然后用作血管内栓塞程序的栓塞材料。体内实验表明，这种水凝胶可以阻塞动脉并阻塞血流，直到最终导致肿瘤和部分健康组织的缺血性坏死。总的来说，当前的LM / CA水凝胶有望被开发为用于将来的肿瘤栓塞治疗的新一代栓塞材料。水凝胶可通过注射器注射在血管中进行，然后用作血管内栓塞程序的栓塞材料。体内实验表明，这种水凝胶可以阻塞动脉并阻塞血流，直到最终导致肿瘤和部分健康组织的缺血性坏死。总的来说，当前的LM / CA水凝胶有望被开发为用于将来的肿瘤栓塞治疗的新一代栓塞材料。水凝胶可通过注射器注射在血管中进行，然后用作血管内栓塞程序的栓塞材料。体内实验表明，这种水凝胶可以阻塞动脉并阻塞血流，直到最终导致肿瘤和部分健康组织的缺血性坏死。总的来说，目前的LM / CA水凝胶有望被开发为用于将来的肿瘤栓塞治疗的新一代栓塞材料。