Systemic dry syndrome affects quality of life, and various effective methods are being developed for its treatment. We recently found that rooibos (Aspalathus linearis) extract activates muscarinic M₃ receptor and improves dryness in mice and humans. We identified eriodictyol-6-C-β-_D-glucoside (E6CG) as the active component affecting the secretory functions of exocrine glands; however, the pharmacokinetics and distribution of E6CG in exocrine glands have not been elucidated in mice receiving rooibos extract. We have developed a quantification method using LC–MS/MS to detect E6CG without an internal standard. Experiments on C57BL/6 mice administered rooibos extract showed that E6CG was transferred into blood plasma, with its concentration levels peaking 19.3 min after treatment. Substantial levels of E6CG were detected in the submandibular, sublingual, parotid, and lacrimal glands and in the sweat glands in palm skin. This study reports that rooibos extracts containing E6CG can be used as functional foods for improving systemic dryness.

系统性干综合症会影响生活质量，目前正在开发各种有效的治疗方法。我们最近发现，rooibos（Aspalathus linearis）提取物可激活毒蕈碱M ₃受体并改善小鼠和人类的干燥感。我们鉴定出了eriodictyol -6- C - β - _D-葡萄糖苷（E6CG）作为影响外分泌腺分泌功能的活性成分；然而，尚未阐明在接受如意宝提取物的小鼠中E6CG在外分泌腺中的药代动力学和分布。我们已经开发出一种使用LC-MS / MS的定量方法，无需内标即可检测E6CG。对使用鼠李糖提取物的C57BL / 6小鼠进行的实验表明，E6CG已转移到血浆中，其浓度水平在治疗后达到19.3分钟。在颌下，舌下，腮腺和泪腺以及棕榈皮肤的汗腺中检测到大量的E6CG。这项研究报告称，含有E6CG的路易波士提取物可用作改善全身干燥的功能性食品。