Hypocrellin Derivative-Loaded Calcium Phosphate Nanorods as NIR Light-Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy.,ChemMedChem

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Hypocrellin Derivative-Loaded Calcium Phosphate Nanorods as NIR Light-Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy.
ChemMedChem ( IF 3.6 ) Pub Date : 2019-11-22 , DOI: 10.1002/cmdc.201900512
Hongyi Wang ₁ , Qingyan Jia _{1,

2} , Weimin Liu _{1,

3} , Fuchun Nan _{1,

3} , Xiuli Zheng _{1,

3} , Ying Ding _{1,

3} , Haohui Ren ₁ , Jiasheng Wu ₁ , Jiechao Ge _{1,

3}

Affiliation

Dopamine modified hypocrellin B (DAHB) derivative-loaded calcium phosphate nanorods (DAHB@CaP NRs) were prepared as a novel phototheranostic agent for effective tumor imaging and therapy. DAHB@CaP NRs were obtained through microwave treatment using DAHB, CaCl2 , NH3 ⋅H2 O, and H3 PO4 as precursors. The DAHB@CaP NRs possessed the following advantages: 1) efficient absorption in the near-infrared (NIR) region from 650 nm to 800 nm; 2) maximum NIR emission at approximately 735 nm; 3) enhanced cellular uptake efficiency in vitro and in vivo; and 4) efficient inhibition of tumor growth and low biotoxicity. These properties indicate the high capability of DAHB@CaP NRs for NIR fluorescence (FL) imaging-guided photodynamic therapy of cancer, thus offering promising new prospects for clinical applications.

中文翻译：

次磷酸酯衍生物磷酸钙纳米棒作为近红外光触发的光热疗剂，具有增强的肿瘤蓄积性，可用于癌症治疗。

制备了多巴胺修饰的hypercrellin B（DAHB）衍生物负载的磷酸钙纳米棒（DAHB @ CaP NRs），作为用于有效肿瘤成像和治疗的新型光热疗剂。DAHB @ CaP NRs是通过以DAHB，CaCl2，NH3·H2O和H3PO4为前体的微波处理获得的。DAHB @ CaP NR具有以下优点：1）在650 nm至800 nm的近红外（NIR）区域有效吸收；2）在大约735 nm处的最大NIR发射；3）提高了体内和体外的细胞吸收效率；和4）有效抑制肿瘤生长和低生物毒性。这些特性表明DAHB @ CaP NRs具有用于NIR荧光（FL）成像引导的光动力疗法的高能力，从而为临床应用提供了有希望的新前景。

更新日期：2019-11-30

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