New treatments are needed to reduce myocardial infarct (MI) size and preserve left ventricular (LV) function, in order to improve clinical outcomes in patients presenting with acute ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI).¹ Remote ischaemic conditioning (RIC), in which brief cycles of ischaemia and reperfusion are applied to an organ or tissue (including a limb) away from the heart, has been shown to reduce MI size in animal models of acute myocardial ischaemia/reperfusion injury (IRI).² The ability to deliver the cardioprotective RIC stimulus by simply inflating and deflating a pneumatic cuff placed on the upper arm or thigh, to induce brief cycles of ischaemia and reperfusion³ has facilitated the translation of RIC into the clinical setting.

中文翻译：

---

为什么在 CONDI-2/ERIC-PPCI 试验中，远程缺血调理不能改善急性心肌梗死的临床结果？

需要新的治疗方法来减少心肌梗死 (MI) 的面积并保留左心室 (LV) 功能，以改善急性 ST 段抬高型心肌梗死 (STEMI) 患者的临床结果，这些患者通过直接经皮冠状动脉介入治疗 (PPCI) . ¹远程缺血调节 (RIC)，即对远离心脏的器官或组织（包括肢体）施加短暂的缺血和再灌注循环，已被证明可减少急性心肌缺血/再灌注损伤动物模型中的 MI 大小(IR)。²能够通过简单地充气和放气放置在上臂或大腿上的充气袖带来提供心脏保护性 RIC 刺激，以诱导短暂的缺血和再灌注循环³ 促进了 RIC 向临床环境的转化。