Biotin interference in high-sensitivity cardiac troponin T testing: a real-world evaluation in acute cardiac care.,Cardiovascular Research

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Biotin interference in high-sensitivity cardiac troponin T testing: a real-world evaluation in acute cardiac care.
Cardiovascular Research ( IF 10.2 ) Pub Date : 2019-12-01 , DOI: 10.1093/cvr/cvz277
Wim H M Vroemen _{1,

2} , William P T M van Doorn _{1,

2} , Dorien M Kimenai _{1,

2} , Will K W H Wodzig _{1,

2} , Douwe de Boer _{1,

2} , Otto Bekers _{1,

2} , Steven J R Meex _{1,

2}

Affiliation

The United States Food and Drug Administration recently issued a safety communication to warn for biotin interference in cardiac troponin assays.¹ Cardiac troponins are the gold standard biomarkers for diagnosing acute myocardial infarction (AMI). Cardiac troponin concentrations can be falsely low in patients using dietary supplements containing high levels of biotin.¹ Since the prevalence of dietary supplement intake is ≥30% in the USA and Europe, substantial clinical concern has risen that AMI might be missed.¹^,² Analytical interference of biotin especially applies to cardiac troponin immunoassays exploiting the biotin–streptavidin interaction in the assay configuration.³ Therefore, we evaluated the real-world prevalence of biotin interference...

中文翻译：

高灵敏度心肌肌钙蛋白 T 测试中的生物素干扰：急性心脏护理中的真实评估。

美国食品和药物管理局最近发布了一份安全通讯，警告生物素干扰心肌肌钙蛋白测定。¹心肌肌钙蛋白是诊断急性心肌梗死 (AMI) 的金标准生物标志物。在使用含有高水平生物素的膳食补充剂的患者中，心肌肌钙蛋白浓度可能会偏低。¹由于美国和欧洲膳食补充剂摄入的流行率 ≥ 30%，因此临床上对可能漏诊 AMI 的担忧日益增加。¹^,²生物素的分析干扰尤其适用于在测定配置中利用生物素-链霉亲和素相互作用的心肌肌钙蛋白免疫测定。³因此，我们评估了生物素干扰的真实世界流行率……

更新日期：2019-10-30

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