当前位置: X-MOL 学术Nat. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A chiral trick to map protein ligandability
Nature Chemistry ( IF 19.2 ) Pub Date : 2019-11-22 , DOI: 10.1038/s41557-019-0380-0
Yuka Amako , Christina M. Woo

Biological receptors distinguish between S- and R-enantiomers and these subtle differences in chirality can lead to vastly different protein affinities. Now, a proteomics approach has been developed that capitalizes on chirality to map enantiomeric probe pairs and provides a rapid and global view of protein ligandability within the cell.

中文翻译:

绘制蛋白质配体性的手性技巧

生物受体区分S和R对映异构体,并且手性的这些细微差别可以导致蛋白质亲和力大大不同。现在,已开发出一种蛋白质组学方法,该方法可利用手性来绘制对映体探针对,并提供细胞内蛋白质配体能力的快速全局视图。
更新日期:2019-11-22
down
wechat
bug