Social exclusion is associated with greater suicide risk and more needs to be known about the biological processes contributing to this association. Oxytocin, a neuropeptide that regulates social interactions, may protect against the negative effects of exclusion by motivating social engagement. Oxytocin levels and desire for social engagement increase when non-psychiatric controls experience acute social exclusion. However, among individuals with borderline personality disorder and chronic depression, oxytocin levels decrease following exclusion. Both of these psychiatric illnesses are associated with high rates of suicidal behavior. No research has examined changes in oxytocin following social exclusion among individuals at risk for suicide. This quasi-experimental study examined differences in oxytocin levels and perceptions of social connectedness following an in-laboratory, acute social exclusion task among (a) individuals with no depression or suicide attempt histories, (b) individuals with current depression symptoms, and (c) individuals with current depression symptoms and suicide attempt histories. Young adults (N = 100) completed self-report measures and provided blood samples before and after an acute social exclusion task (Cyberball). Oxytocin was quantified via enzyme-linked immunosorbent assay. Mixed-design ANCOVAs were used to evaluate changes in unextracted and extracted oxytocin levels, desire for emotional support, thwarted belongingness, and perceived burdensomeness. Among suicide attempters, unextracted oxytocin levels decreased and desire for emotional support did not significantly change following exclusion. Among depressed and healthy controls, desire for emotional support increased and unextracted oxytocin levels did not significantly change. No significant changes in extracted oxytocin levels, thwarted belongingness and perceived burdensomeness emerged. Further research is needed to determine if dysregulated oxytocin-related processes biologically predispose individuals with suicide attempt histories to greater social disconnection and suicide risk.

中文翻译：

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在有自杀未遂史的年轻成年人中，实验室内社交排斥后未提取血浆催产素水平下降。

社会排斥与更大的自杀风险相关联，并且需要更多地了解促成这种关联的生物过程。催产素是一种调节社会互动的神经肽，可以通过激发社会参与来防止排斥的负面影响。当非精神病控制者经历了急性的社会排斥时，催产素水平和对社会参与的渴望就会增加。但是，在患有边缘性人格障碍和慢性抑郁的个体中，催产素水平在排除后会下降。这两种精神疾病都与高自杀行为有关。在有自杀风险的人中被社会排斥后，没有研究检查催产素的变化。这项准实验研究调查了（a）没有抑郁或自杀未遂史的人，（b）有当前抑郁症状的人和（c）在实验室内进行的急性社会排斥任务后催产素水平和社交联系感的差异。 ）当前有抑郁症状和自杀未遂史的人。年轻人（N = 100）完成了自我报告措施，并在急性社会排斥任务（赛博球）之前和之后提供了血液样本。催产素通过酶联免疫吸附测定进行定量。混合设计的ANCOVA用于评估未提取和提取的催产素水平，对情感支持的渴望，挫败的归属感和感觉的负担感的变化。在自杀未遂中，排除后未提取的催产素水平降低，对情感支持的渴望没有明显改变。在抑郁和健康的对照组中，对情感支持的渴望增加，未提取的催产素水平没有显着变化。提取的催产素水平，受挫的归属感和可察觉的负担感没有出现明显变化。需要进一步的研究来确定催产素相关过程失调是否在生物学上使具有自杀未遂史的人更容易陷入社会分裂和自杀风险。挫败了归属感和负担感。需要进一步的研究来确定催产素相关过程失调是否在生物学上使具有自杀未遂史的人更容易陷入社会分裂和自杀风险。挫败了归属感和负担感。需要进一步的研究来确定催产素相关过程失调是否在生物学上使具有自杀未遂史的人更容易陷入社会分裂和自杀风险。