Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism.,Molecular Nutrition & Food Research

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Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2019-12-15 , DOI: 10.1002/mnfr.201900789
Yang Zhang _{1,

2} , Gerd Bobe _{1,

3} , Johana S Revel _{1,

4} , Richard R Rodrigues ₅ , Thomas J Sharpton _{6,

7} , Mary L Fantacone _{1,

8} , Kareem Raslan ₆ , Cristobal L Miranda _{1,

5} , Malcolm B Lowry _{1,

6} , Paul R Blakemore ₄ , Andrey Morgun ₅ , Natalia Shulzhenko ₉ , Claudia S Maier _{1,

4} , Jan F Stevens _{1,

5} , Adrian F Gombart _{1,

2,

8}

Affiliation

Two hydrogenated xanthohumol (XN) derivatives, α,β‐dihydro‐XN (DXN) and tetrahydro‐XN (TXN), improved parameters of metabolic syndrome (MetS), a critical risk factor of cardiovascular disease (CVD) and type 2 diabetes, in a diet‐induced obese murine model. It is hypothesized that improvements in obesity and MetS are linked to changes in composition of the gut microbiota, bile acid metabolism, intestinal barrier function, and inflammation.

中文翻译：

黄腐酚衍生物改善代谢综合征与改变肠道微生物群和胆汁酸代谢有关。

两种氢化黄腐酚 (XN) 衍生物，α,β-二氢-XN (DXN) 和四氢-XN (TXN)，改善了代谢综合征 (MetS) 的参数，代谢综合征 (MetS) 是心血管疾病 (CVD) 和 2 型糖尿病的关键危险因素，在饮食诱导的肥胖小鼠模型中。据推测，肥胖和代谢综合征的改善与肠道微生物群组成、胆汁酸代谢、肠道屏障功能和炎症的变化有关。

更新日期：2019-12-15

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