Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides,Organic Chemistry Frontiers

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Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2019-11-22 , DOI: 10.1039/c9qo01228a
Shiwen Liu _{1,

2,

3,

4,

5} , Xiaojun Zeng _{5,

6,

7,

8,

9} , Bo Xu _{5,

6,

7,

8,

9}

Affiliation

We have developed highly efficient fluorothiolation and difluorothiolation of alkenes under simple and mild conditions. Our fluorothiolation reagents are the commercially available Olah's reagent (Py-HF) and readily available N-thiosuccinimides. This transition metal-free system offers good chemical yields for a wide range of alkene substrates with excellent regioselectivity and good functional group tolerance.

中文翻译：

使用吡啶-HF和N-硫代琥珀酰亚胺对烯烃进行实际的氟代硫化和二氟代硫代化

我们已经在简单温和的条件下开发出了高效的烯烃氟硫代和二氟硫代化。我们的氟硫代试剂是可商购的Olah试剂（Py-HF）和现成的N-硫代琥珀酰亚胺。这种不含过渡金属的系统可为多种烯烃底物提供良好的化学收率，具有出色的区域选择性和良好的官能团耐受性。

更新日期：2019-11-22

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