Recent advances in the synthesis of indoles from alkynes and nitrogen sources,Organic Chemistry Frontiers

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Recent advances in the synthesis of indoles from alkynes and nitrogen sources
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2019-11-22 , DOI: 10.1039/c9qo01315f
José Sebastião Santos Neto _{1,

2,

3,

4,

5} , Gilson Zeni _{1,

2,

3,

4,

5}

Affiliation

Transition metal-catalyzed cyclization reactions of unsaturated substrates have become one of the most important and useful methodologies for the preparation of heterocycles. To this end, the association between alkynes and nitrogen compounds results in versatile substrates for the synthesis of N-heterocycles, including indole derivatives. In order to demonstrate the growth in this area, this review highlights ten years of success in the synthesis of indoles using alkynes and nitrogen sources as substrates in the cyclization reactions catalyzed by metals. We believe that summarizing these methods would be very useful for the chemists who are interested in the synthesis of N-heterocycles.

中文翻译：

炔烃和氮源合成吲哚的最新进展

过渡金属催化的不饱和底物的环化反应已成为制备杂环的最重要和最有用的方法之一。为此，炔烃和氮化合物之间的缔合产生了用于合成N-杂环的通用底物，包括吲哚衍生物。为了证明这一领域的增长，本综述重点介绍了在使用炔烃和氮源作为金属催化的环化反应底物的吲哚合成中的十年成功经验。我们认为，总结这些方法对于对N杂环的合成感兴趣的化学家将非常有用。

更新日期：2019-11-22

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