Rhodium-catalyzed homodimerization–cyclization reaction of two vinyl isocyanides: a general route to 2-(isoquinolin-1-yl)oxazoles,Organic Chemistry Frontiers

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Rhodium-catalyzed homodimerization–cyclization reaction of two vinyl isocyanides: a general route to 2-(isoquinolin-1-yl)oxazoles
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2019-11-22 , DOI: 10.1039/c9qo01229j
Zhuo Wang _{1,

2,

3,

4,

5} , Xiang-He Meng _{1,

2,

3,

4,

5} , Pei Liu _{1,

2,

3,

4,

5} , Wan-Ying Hu _{1,

2,

3,

4,

5} , Yu-Long Zhao _{1,

2,

3,

4,

5}

Affiliation

A novel rhodium-catalyzed homodimerization–cyclization reaction of two vinyl isocyanides has been developed for the first time. In this reaction, the highly reactive 1,4-diazabutatriene intermediates generated by the homodimerization of two vinyl isocyanides could undergo a novel type of intramolecular tandem cyclization and provides a new and highly efficient method for the construction of 2-(isoquinolin-1-yl)oxazoles by formation of three new bonds and two rings from readily available acyclic starting materials in a single step.

中文翻译：

铑催化的两个乙烯基异氰酸酯的均二聚-环化反应：2-（异喹啉-1-基）恶唑的一般路线

首次开发了一种新颖的铑催化的二乙烯基异氰酸酯的均二聚-环化反应。在此反应中，由两个乙烯基异氰化物均二聚生成的高反应性1,4-二氮杂丁三烯中间体可能会经历新型的分子内串联环化反应，并为构建2-（异喹啉-1-基）提供了一种新的高效方法。恶唑类化合物，只需一步就可以从容易获得的无环起始原料中形成三个新的键和两个环。

更新日期：2019-11-22

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