BACKGROUND Sleep disordered breathing (SDB) is a common disorder that results in oxidative stress and inflammation and is associated with multiple age-related health outcomes. Epigenetic age acceleration is a DNA methylation (DNAm)-based marker of fast biological aging. We examined the associations of SDB traits with epigenetic age acceleration. METHODS A sample of 622 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) had blood DNAm measured and underwent Type 2 in-home polysomnography that assessed apnea-hypopnea index (AHI), percentage of sleep time with oxygen saturation lower than 90% (Per90), and arousal index. DNAm data provided measures of DNAm-Age acceleration and DNAm-PhenoAge acceleration. The association of each SDB trait with age acceleration was estimated using linear regression, controlling for covariates. In secondary analyses, we studied the associations of SDB traits with epigenetic age acceleration 2-10 years after sleep study in 530 individuals from the Framingham Heart Study (FHS). FINDINGS In MESA, AHI was associated with greater DNAm-PhenoAge acceleration (β = 0.03; 95% CI [0.001, 0.06]). Arousal index was associated with greater DNAm-Age acceleration (β = 0.04; 95% CI [0.01, 0.07]). Both associations were stronger in women than men. In the secondary FHS analyses, Per90 was associated with greater DNAm-Age acceleration and this association was stronger in men. INTERPRETATION More severe SDB was associated with epigenetic age acceleration in both cohorts. Future work should prospectively study short- and long-term effects of SDB, and whether treatment reduces epigenetic age acceleration among those individuals with SBD. FUNDING National Institutes of Health.

中文翻译：

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睡眠呼吸障碍与表观遗传年龄加速之间的关联：来自动脉粥样硬化多种族研究的证据。

背景睡眠呼吸障碍（SDB）是一种常见的疾病，会导致氧化应激和炎症，并与多种与年龄相关的健康结果相关。表观遗传年龄加速是一种基于 DNA 甲基化 (DNAm) 的快速生物衰老标志物。我们研究了 SDB 性状与表观遗传年龄加速的关联。方法 对来自动脉粥样硬化多种族研究 (MESA) 的 622 名参与者的样本进行了血液 DNAm 测量，并接受了 2 型家庭多导睡眠图评估呼吸暂停低通气指数 (AHI)、氧饱和度低于 90% 的睡眠时间百分比(Per90) 和唤醒指数。DNAm 数据提供了 DNAm-Age 加速和 DNAm-PhenoAge 加速的测量。使用线性回归估计每个 SDB 特征与年龄加速的关联，控制协变量。在二级分析中，我们研究了来自弗雷明汉心脏研究 (FHS) 的 530 名个体在睡眠研究后 2-10 年的 SDB 特征与表观遗传年龄加速的关联。在 MESA 中，AHI 与更大的 DNAm-PhenoAge 加速相关（β = 0.03；95% CI [0.001, 0.06]）。唤醒指数与更大的 DNAm-Age 加速相关（β = 0.04；95% CI [0.01, 0.07]）。这两种关联在女性中都比男性强。在二级 FHS 分析中，Per90 与更大的 DNAm-Age 加速相关，并且这种关联在男性中更强。解释 两个队列中更严重的 SDB 与表观遗传年龄加速相关。未来的工作应该前瞻性地研究 SDB 的短期和长期影响，以及治疗是否会降低 SBD 患者的表观遗传年龄加速。