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Double layers of gold nanoparticles immobilized titanium implants improve the osseointegration in rabbit models.
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2019-11-21 , DOI: 10.1016/j.nano.2019.102129 Wan-Kyu Ko 1 , Seong Jun Kim 1 , Dong Nyoung Heo 2 , In-Bo Han 3 , Sewha Kim 4 , Il Keun Kwon 2 , Seil Sohn 3
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2019-11-21 , DOI: 10.1016/j.nano.2019.102129 Wan-Kyu Ko 1 , Seong Jun Kim 1 , Dong Nyoung Heo 2 , In-Bo Han 3 , Sewha Kim 4 , Il Keun Kwon 2 , Seil Sohn 3
Affiliation
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Osseointegration is important in osteopenia and osteoporosis patients due to their low bone densities. Gold nanoparticles (GNPs) are greatly beneficial materials as osteogenic agents. The aim of this study is to investigate osseointegration between bones and double layers of GNP-immobilized titanium (Ti) implants. The physicochemical properties of the Ti surface were evaluated by scanning electron microscopy, by atomic force microscopy, by means of the contact angle using water drops, and by x-ray photoelectron spectroscopy. Osteogenic differentiation of human bone-marrow-derived mesenchymal stem cells was analyzed and showed the higher values in double layers of GNP (GNP2) groups. In addition, we performed an in vivo study using hydroxyapatite (HA) and GNP2 spine pedicle screws in ovariectomized (OVX) and SHAM rabbits. Osseointegration parameters also showed higher values in GNP2 than in HA groups. These findings suggest that implants with double layers of GNPs can be a useful alternative in osteoporotic patients.
中文翻译：
双层金纳米颗粒固定的钛植入物改善了兔模型的骨整合。
由于骨密度低，骨整合在骨质减少和骨质疏松症患者中很重要。金纳米颗粒（GNP）作为成骨剂是非常有益的材料。这项研究的目的是研究骨骼与固定有GNP的钛（Ti）植入物的双层之间的骨整合。通过扫描电子显微镜，原子力显微镜，利用水滴的接触角和X射线光电子能谱评价Ti表面的物理化学性质。分析了人骨髓来源的间充质干细胞的成骨分化，并显示了双层GNP（GNP2）组中较高的值。此外，我们在卵巢切除（OVX）和SHAM兔中使用羟基磷灰石（HA）和GNP2脊柱椎弓根螺钉进行了体内研究。骨整合参数在GNP2中也显示出比HA组更高的值。这些发现表明，在骨质疏松症患者中，双层GNPs植入物可能是有用的替代方法。
更新日期：2019-11-22
中文翻译：
双层金纳米颗粒固定的钛植入物改善了兔模型的骨整合。
由于骨密度低，骨整合在骨质减少和骨质疏松症患者中很重要。金纳米颗粒（GNP）作为成骨剂是非常有益的材料。这项研究的目的是研究骨骼与固定有GNP的钛（Ti）植入物的双层之间的骨整合。通过扫描电子显微镜，原子力显微镜，利用水滴的接触角和X射线光电子能谱评价Ti表面的物理化学性质。分析了人骨髓来源的间充质干细胞的成骨分化，并显示了双层GNP（GNP2）组中较高的值。此外，我们在卵巢切除（OVX）和SHAM兔中使用羟基磷灰石（HA）和GNP2脊柱椎弓根螺钉进行了体内研究。骨整合参数在GNP2中也显示出比HA组更高的值。这些发现表明，在骨质疏松症患者中，双层GNPs植入物可能是有用的替代方法。
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