A series of hemi-indigo derivatives was synthesized and their photoswitching properties in aqueous medium were studied. The dimethoxy hemi-indigo derivative with the best photochromic performance in water was identified as a promising platform for the development of photoswitchable binders for biomolecules. The synthetic approach towards the introduction of the alkylamino pendant to the dimethoxy hemi-indigo core was developed that allowed to obtain an RNA-binding hemi-indigo derivative with photoswitchable fluorescent properties.

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用于生物应用的水溶性半靛蓝光电开关的设计，合成和研究

合成了一系列半靛蓝衍生物，研究了它们在水介质中的光开关性能。在水中具有最佳光致变色性能的二甲氧基半靛蓝衍生物被认为是开发用于生物分子的可光转换粘合剂的有前途的平台。开发了将烷基氨基侧基引入二甲氧基半靛蓝核心的合成方法，该方法允许获得具有光开关荧光特性的结合RNA的半靛蓝衍生物。