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Patterning and polarization of cells by intracellular flows.
Current Opinion in Cell Biology ( IF 7.5 ) Pub Date : 2019-11-21 , DOI: 10.1016/j.ceb.2019.10.005
Rukshala Illukkumbura 1 , Tom Bland 2 , Nathan W Goehring 3
Affiliation  

Beginning with Turing's seminal work [1], decades of research have demonstrated the fundamental ability of biochemical networks to generate and sustain the formation of patterns. However, it is increasingly appreciated that biochemical networks also both shape and are shaped by physical and mechanical processes [2, 3, 4]. One such process is fluid flow. In many respects, the cytoplasm, membrane and actin cortex all function as fluids, and as they flow, they drive bulk transport of molecules throughout the cell. By coupling biochemical activity to long-range molecular transport, flows can shape the distributions of molecules in space. Here, we review the various types of flows that exist in cells, with the aim of highlighting recent advances in our understanding of how flows are generated and how they contribute to intracellular patterning processes, such as the establishment of cell polarity.

中文翻译:

通过细胞内流动对细胞进行图案化和极化。

从图灵的开创性工作 [1] 开始,数十年的研究已经证明了生化网络产生和维持模式形成的基本能力。然而,人们越来越认识到,生化网络也可以通过物理和机械过程形成和形成 [2, 3, 4]。一种这样的过程是流体流动。在许多方面,细胞质、细胞膜和肌动蛋白皮层都起到流体的作用,当它们流动时,它们驱动分子在整个细胞中的大量运输。通过将生化活动与远程分子传输相结合,流动可以塑造分子在空间中的分布。在这里,我们回顾了细胞中存在的各种类型的流,
更新日期:2019-11-21
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