OBJECTIVE To assess site variability and concomitant respiratory support related to the timing of caffeine discontinuation, and compare clinical characteristics of infants who discontinued caffeine before vs. within the last week of hospitalization. STUDY DESIGN Cohort study of 81,110 infants <35 weeks gestational age and <1500 g birth weight discharged from 304 neonatal intensive care units from 2001-2016. RESULTS The mean postmenstrual age at caffeine discontinuation ranged from 32 to 37 weeks among sites. Respiratory support at the time of discontinuation was common, but variable, with 0-57% of infants receiving positive airway pressure at caffeine discontinuation by site. Infants who discontinued caffeine within the last week of hospitalization had longer total duration of caffeine, but were discharged from the hospital at an earlier postmenstrual age. CONCLUSION There was substantial variability among sites in the timing of caffeine discontinuation before discharge and respiratory support at the time of caffeine discontinuation.

中文翻译：

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早产儿咖啡因停药时间的差异很大。

目的评估与咖啡因停用时间有关的部位变异性和伴随的呼吸支持，并比较住院前和住院最后一周内停用咖啡因的婴儿的临床特征。研究设计从2001年至2016年，对304个新生儿重症监护病房出院的81,110名<35周胎龄和<1500 g出生体重的婴儿进行了队列研究。结果各部位咖啡因停药后的平均月经年龄为32至37周。停药时的呼吸支持很常见，但有所不同，有0-57％的婴儿因咖啡因停药而接受气道正压通气。在住院的最后一周内停用咖啡因的婴儿的总咖啡因持续时间较长，但在月经后更早就出院了。结论出院前咖啡因停药时间和咖啡因停药时呼吸支持的部位之间存在很大差异。