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Dietary Uptake and Depuration Kinetics of Perfluorooctane Sulfonate, Perfluorooctanoic Acid, and Hexafluoropropylene Oxide Dimer Acid (GenX) in a Benthic Fish.
Environmental Toxicology and Chemistry ( IF 3.6 ) Pub Date : 2020-01-24 , DOI: 10.1002/etc.4640
Kathryn L Hassell 1, 2 , Timothy L Coggan 3 , Tom Cresswell 4 , Adam Kolobaric 3 , Kathryn Berry 3 , Nicholas D Crosbie 5 , Judy Blackbeard 5 , Vincent J Pettigrove 1, 2 , Bradley O Clarke 3
Affiliation  

Per- and poly-fluoroalkyl substances (PFAS) are ubiquitously distributed throughout aquatic environments and can bioaccumulate in organisms. We examined dietary uptake and depuration of a mixture of 3 PFAS: perfluorooctanoic acid (PFOA; C8 HF15 O2 ), perfluorooctane sulfonate (PFOS; C8 HF17 SO3 ), and hexafluoropropylene oxide dimer acid (HPFO-DA; C6 HF11 O3 ; trade name GenX). Benthic fish (blue spot gobies, Pseudogobius sp.) were fed contaminated food (nominal dose 500 ng g-1 ) daily for a 21-d uptake period, followed by a 42-d depuration period. The compounds PFOA, linear-PFOS (linear PFOS), and total PFOS (sum of linear and branched PFOS) were detected in freeze-dried fish, whereas GenX was not, indicating either a lack of uptake or rapid elimination (<24 h). Depuration rates (d-1 ) were 0.150 (PFOA), 0.045 (linear-PFOS), and 0.042 (linear+branched-PFOS) with corresponding biological half-lives of 5.9, 15, and 16 d, respectively. The PFOS isomers were eliminated differently, resulting in enrichment of linear-PFOS (70-90%) throughout the depuration period. The present study is the first reported study of GenX dietary bioaccumulation potential in fish, and the first dietary study to investigate uptake and depuration of multiple PFASs simultaneously, allowing us to determine that whereas PFOA and PFOS accumulated as expected, GenX, administered in the same way, did not appear to bioaccumulate. Environ Toxicol Chem 2020;39:595-603. © 2019 SETAC.

中文翻译:

底栖鱼类中全氟辛烷磺酸盐,全氟辛酸和六氟环氧丙烷二聚酸(GenX)的饮食摄取和净化动力学。

全氟烷基物质和全氟烷基物质(PFAS)遍及整个水生环境,并且可以在生物体中生物富集。我们检查了以下三种PFAS混合物的饮食摄取和净化情况:全氟辛酸(PFOA; C8 HF15 O2),全氟辛烷磺酸盐(PFOS; C8 HF17 SO3)和六氟环氧丙烷二聚酸(HPFO-DA; C6 HF11 O3;商品名称GenX )。每天向底栖鱼类(蓝斑虾虎鱼,Pseudogobius sp。)喂食受污染的食物(标称剂量500 ng g-1),持续21天的摄取期,然后进行42天的净化期。在冻干鱼中检测到化合物PFOA,线性PFOS(线性PFOS)和总PFOS(线性和分支PFOS的总和),而未检测到GenX,表明缺乏摄取或快速消除(<24小时) 。净化率(d-1)为0.150(PFOA),0.045(linear-PFOS)和0。042(线性+支链PFOS),相应的生物学半衰期分别为5.9、15和16 d。PFOS异构体的清除方式有所不同,从而在整个纯化期间都富集了线性PFOS(70-90%)。本研究是第一个报告的GenX鱼类在鱼类中生物富集潜力的研究,也是第一个同时研究多种PFAS的摄取和净化的饮食研究,这使我们能够确定,PFOA和PFOS可以按预期的方式积累,而GenX可以同时施用方式,似乎没有生物蓄积。Environ Toxicol Chem 2020; 39:595-603。©2019 SETAC。本研究是第一个报告的GenX鱼类在鱼类中生物富集潜力的研究,也是第一个同时研究多种PFAS的摄取和净化的饮食研究,这使我们能够确定,PFOA和PFOS可以按预期的方式积累,而GenX可以同时施用方式,似乎没有生物蓄积。Environ Toxicol Chem 2020; 39:595-603。©2019 SETAC。本研究是第一个报告的GenX鱼类在鱼类中生物富集潜力的研究,也是第一个同时研究多种PFAS的摄取和净化的饮食研究,这使我们能够确定,PFOA和PFOS可以按预期的方式积累,而GenX可以同时施用方式,似乎没有生物蓄积。Environ Toxicol Chem 2020; 39:595-603。©2019 SETAC。
更新日期:2020-02-27
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