Many patients with epilepsy have both focal and bilateral tonic‐clonic seizures (BTCSs), but it is largely unclear why ictal activity spreads only sometimes. Previous work indicates that interictal high‐frequency oscillations (HFOs), traditionally subdivided into ripples (80–250 Hz) and fast ripples (250–500 Hz), are a promising biomarker of epileptogenicity. We aimed to investigate whether HFOs correlate with the emergence of seizure activity and whether they differ between focal seizures (FSs) with impaired awareness and BTCSs.

中文翻译：

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高频振荡反映了人类颞叶癫痫发作的严重程度。

许多癫痫患者既有局灶性发作又有双侧强直性阵挛性发作（BTCSs），但是目前尚不清楚为什么发作有时仅散播的原因尚不清楚。先前的工作表明，传统上细分为高频（HFO）的波纹（80-250 Hz）和快速波纹（250-500 Hz）是癫痫发生的有前途的生物标志。我们旨在调查HFO是否与癫痫发作的发生有关，以及在意识受损的BT和BTCS之间是否存在差异。