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Delivering nitric oxide into human skin from encapsulated S-nitrosoglutathione under UV light: An in vitro and ex vivo study.
Nitric Oxide ( IF 3.2 ) Pub Date : 2019-11-21 , DOI: 10.1016/j.niox.2019.11.003 Milena T Pelegrino 1 , Richard B Weller 2 , André Paganotti 3 , Amedea B Seabra 1
Nitric Oxide ( IF 3.2 ) Pub Date : 2019-11-21 , DOI: 10.1016/j.niox.2019.11.003 Milena T Pelegrino 1 , Richard B Weller 2 , André Paganotti 3 , Amedea B Seabra 1
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Nitric oxide (NO) is a crucial molecule in the human body. The encapsulation of exogenous NO donors into chitosan nanoparticles (CS NPs) has been widely used to overcome NO drawbacks in pharmacological applications, such as, its short half-life. The NO donor, S-nitrosoglutathione (GSNO), was encapsulated into CS NPs (GSNO-CS NPs) and characterized by AFM and DLS measurements. The nanoparticles presented a hydrodynamic size of 123.3 ± 1.5 nm and a polydispersity of 0.25 ± 0.01. The ability of GSNO-CS NPs, combined with UV irradiation, to deliver NO was evaluated using ex vivo human skin. The human skin was pre-treated with GSNO-CS NPs, in the presence and absence of UV irradiation. The results showed that the combined treatment significantly increased the NO and S-nitrosothiol levels in human skin. This effect can emulate the cardiovascular benefits related to NO without negative side effects of skin exposure to UV light.
中文翻译：
在紫外线下从封装的S-亚硝基谷胱甘肽向人体皮肤中释放一氧化氮：一项体外和离体研究。
一氧化氮（NO）是人体中的关键分子。外源NO供体在壳聚糖纳米颗粒（CS NPs）中的封装已被广泛用于克服NO在药理学应用中的缺点，例如半衰期短。将NO供体S-亚硝基谷胱甘肽（GSNO）封装到CS NP（GSNO-CS NP）中，并通过AFM和DLS测量进行表征。纳米颗粒的流体力学尺寸为123.3±1.5 nm，多分散度为0.25±0.01。使用离体人体皮肤评估了GSNO-CS NP与紫外线辐射结合释放NO的能力。在存在和不存在紫外线照射的情况下，用GSNO-CS NP对人的皮肤进行预处理。结果表明，联合治疗显着提高了人皮肤中的NO和S-亚硝基硫醇水平。
更新日期：2019-11-21
中文翻译：
在紫外线下从封装的S-亚硝基谷胱甘肽向人体皮肤中释放一氧化氮：一项体外和离体研究。
一氧化氮（NO）是人体中的关键分子。外源NO供体在壳聚糖纳米颗粒（CS NPs）中的封装已被广泛用于克服NO在药理学应用中的缺点，例如半衰期短。将NO供体S-亚硝基谷胱甘肽（GSNO）封装到CS NP（GSNO-CS NP）中，并通过AFM和DLS测量进行表征。纳米颗粒的流体力学尺寸为123.3±1.5 nm，多分散度为0.25±0.01。使用离体人体皮肤评估了GSNO-CS NP与紫外线辐射结合释放NO的能力。在存在和不存在紫外线照射的情况下，用GSNO-CS NP对人的皮肤进行预处理。结果表明，联合治疗显着提高了人皮肤中的NO和S-亚硝基硫醇水平。
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