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Emerging aqueous two-phase systems: from fundamentals of interfaces to biomedical applications.
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2019-11-21 , DOI: 10.1039/c9cs00466a
Youchuang Chao 1 , Ho Cheung Shum
Affiliation  

Aqueous two-phase systems (ATPSs) have been recognized for their applications in extraction, separation, purification, and enrichment of (bio)molecules and cells. Recently, their unique ability to create aqueous–aqueous interfaces through phase separation and the characteristics of these interfaces have created new opportunities in biomedical applications. In this review, we summarize recent progress in understanding the dynamics at aqueous–aqueous interfaces, and in developing interface-assisted design of artificial cells and cyto-mimetic materials, fabrication of cyto- and bio-compatible microparticles, cell micropatterning, 3D bioprinting, and microfluidic separation of cells and biomolecules. We also discuss the challenges and perspectives to leverage the unique characteristics of ATPSs and their interfaces in broader applications.

中文翻译:

新兴的水相两相系统:从界面原理到生物医学应用。

两相水相系统(ATPSs)因其在(生物)分子和细胞的提取,分离,纯化和富集中的应用而得到认可。最近,它们通过相分离产生水-水界面的独特能力以及这些界面的特性为生物医学应用创造了新的机遇。在这篇综述中,我们总结了在了解水-水界面动力学方面的最新进展,以及在开发人工细胞和模拟细胞材料的界面辅助设计,细胞和生物相容性微粒的制造,细胞微图案化,3D生物打印,以及细胞和生物分子的微流分离。我们还将讨论在更广泛的应用中利用ATPS及其接口的独特特性所面临的挑战和前景。
更新日期:2019-11-21
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