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Downregulation of microR-147b represses the proliferation and invasion of thyroid carcinoma cells by inhibiting Wnt/β-catenin signaling via targeting SOX15.
Molecular and Cellular Endocrinology ( IF 3.8 ) Pub Date : 2019-11-21 , DOI: 10.1016/j.mce.2019.110662 Chongwen Xu 1 , Junsong Liu 1 , Xiaobao Yao 1 , Yanxia Bai 1 , Qian Zhao 1 , Ruimin Zhao 1 , Bo Kou 1 , Honghui Li 1 , Peng Han 1 , Xuan Wang 1 , Longwei Guo 2 , Zhiwei Zheng 3 , Shaoqiang Zhang 1
Molecular and Cellular Endocrinology ( IF 3.8 ) Pub Date : 2019-11-21 , DOI: 10.1016/j.mce.2019.110662 Chongwen Xu 1 , Junsong Liu 1 , Xiaobao Yao 1 , Yanxia Bai 1 , Qian Zhao 1 , Ruimin Zhao 1 , Bo Kou 1 , Honghui Li 1 , Peng Han 1 , Xuan Wang 1 , Longwei Guo 2 , Zhiwei Zheng 3 , Shaoqiang Zhang 1
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microRNA-147b (miR-147b) is a newly identified tumor-related miRNA that is dysregulated in multiple cancer types. Yet, the role of miR-147b in thyroid carcinoma remains unknown. Herein, we found that miR-147b expression was upregulated in thyroid carcinoma tissues and cell lines. miR-147b inhibition decreased the proliferation, colony formation, and invasion of thyroid carcinoma cells. The tumor suppressive gene SRY-related high-mobility-group box gene 15 (SOX15) was predicted as a miR-147b target gene. SOX15 expression was markedly decreased in thyroid carcinoma tissues and inversely correlated with the miR-147b expression. SOX15 overexpression repressed the proliferation and invasion of thyroid carcinoma cells associated with downregulation of Wnt/β-catenin signaling. SOX15 knockdown abolished the miR-147b-inhibition-mediated antitumor effect. miR-147b inhibition or SOX15 overexpression retarded the tumor growth of thyroid carcinoma cells in vivo. Overall, our study suggests that miR-147b inhibition restrains the proliferation and invasion of thyroid carcinoma cells through upregulation of SOX15 and inhibition of Wnt/β-catenin signaling.
中文翻译：
microR-147b的下调通过靶向SOX15抑制Wnt /β-catenin信号传导，从而抑制甲状腺癌细胞的增殖和侵袭。
microRNA-147b（miR-147b）是一种新近鉴定出的与肿瘤相关的miRNA，在多种癌症类型中表达异常。然而，miR-147b在甲状腺癌中的作用仍然未知。在本文中，我们发现在甲状腺癌组织和细胞系中miR-147b表达被上调。miR-147b抑制作用会降低甲状腺癌细胞的增殖，集落形成和侵袭。肿瘤抑制基因SRY相关的高迁移率族盒基因15（SOX15）被预测为miR-147b靶基因。甲状腺癌组织中SOX15的表达明显降低，与miR-147b的表达呈负相关。SOX15过表达抑制与Wnt /β-catenin信号转导下调相关的甲状腺癌细胞的增殖和侵袭。SOX15敲低废除了miR-147b抑制介导的抗肿瘤作用。miR-147b抑制或SOX15过表达可抑制体内甲状腺癌细胞的肿瘤生长。总体而言，我们的研究表明，miR-147b抑制通过上调SOX15和抑制Wnt /β-catenin信号传导来抑制甲状腺癌细胞的增殖和侵袭。
更新日期：2019-11-21
中文翻译：
microR-147b的下调通过靶向SOX15抑制Wnt /β-catenin信号传导，从而抑制甲状腺癌细胞的增殖和侵袭。
microRNA-147b（miR-147b）是一种新近鉴定出的与肿瘤相关的miRNA，在多种癌症类型中表达异常。然而，miR-147b在甲状腺癌中的作用仍然未知。在本文中，我们发现在甲状腺癌组织和细胞系中miR-147b表达被上调。miR-147b抑制作用会降低甲状腺癌细胞的增殖，集落形成和侵袭。肿瘤抑制基因SRY相关的高迁移率族盒基因15（SOX15）被预测为miR-147b靶基因。甲状腺癌组织中SOX15的表达明显降低，与miR-147b的表达呈负相关。SOX15过表达抑制与Wnt /β-catenin信号转导下调相关的甲状腺癌细胞的增殖和侵袭。SOX15敲低废除了miR-147b抑制介导的抗肿瘤作用。miR-147b抑制或SOX15过表达可抑制体内甲状腺癌细胞的肿瘤生长。总体而言，我们的研究表明，miR-147b抑制通过上调SOX15和抑制Wnt /β-catenin信号传导来抑制甲状腺癌细胞的增殖和侵袭。
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