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A major role for common genetic variation in anxiety disorders.
Molecular Psychiatry ( IF 9.6 ) Pub Date : 2019-11-20 , DOI: 10.1038/s41380-019-0559-1 Kirstin L Purves 1 , Jonathan R I Coleman 1, 2 , Sandra M Meier 3, 4, 5 , Christopher Rayner 1 , Katrina A S Davis 2, 6 , Rosa Cheesman 1 , Marie Bækvad-Hansen 5, 7 , Anders D Børglum 5, 8, 9 , Shing Wan Cho 1 , J Jürgen Deckert 10 , Héléna A Gaspar 1, 2 , Jonas Bybjerg-Grauholm 5, 7 , John M Hettema 11 , Matthew Hotopf 2, 6 , David Hougaard 5, 7 , Christopher Hübel 1, 2, 12 , Carol Kan 13 , Andrew M McIntosh 14, 15 , Ole Mors 4, 5 , Preben Bo Mortensen 5, 9, 16 , Merete Nordentoft 5, 17 , Thomas Werge 5, 18, 19 , Kristin K Nicodemus 20 , Manuel Mattheisen 5, 8, 10, 21 , Gerome Breen 1, 2 , Thalia C Eley 1, 2
Molecular Psychiatry ( IF 9.6 ) Pub Date : 2019-11-20 , DOI: 10.1038/s41380-019-0559-1 Kirstin L Purves 1 , Jonathan R I Coleman 1, 2 , Sandra M Meier 3, 4, 5 , Christopher Rayner 1 , Katrina A S Davis 2, 6 , Rosa Cheesman 1 , Marie Bækvad-Hansen 5, 7 , Anders D Børglum 5, 8, 9 , Shing Wan Cho 1 , J Jürgen Deckert 10 , Héléna A Gaspar 1, 2 , Jonas Bybjerg-Grauholm 5, 7 , John M Hettema 11 , Matthew Hotopf 2, 6 , David Hougaard 5, 7 , Christopher Hübel 1, 2, 12 , Carol Kan 13 , Andrew M McIntosh 14, 15 , Ole Mors 4, 5 , Preben Bo Mortensen 5, 9, 16 , Merete Nordentoft 5, 17 , Thomas Werge 5, 18, 19 , Kristin K Nicodemus 20 , Manuel Mattheisen 5, 8, 10, 21 , Gerome Breen 1, 2 , Thalia C Eley 1, 2
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Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.
中文翻译：
常见遗传变异在焦虑症中的主要作用。
焦虑症是常见、复杂的精神疾病，双胞胎遗传率为 30-60%。我们对终生焦虑症进行了全基因组关联研究（ncase = 25 453，ncontrol = 58 113），并对当前焦虑症状进行了额外分析（ncase = 19 012，ncontrol = 58 113）。终身焦虑症的责任量表常见变异遗传力估计为 26%，当前焦虑症状的责任量表常见变异遗传力估计为 31%。鉴定出五个新的全基因组重要位点，包括 9 号染色体上的一个基因间区域，该区域先前与神经质有关，以及一个与 BDNF 受体基因 NTRK2 重叠的位点。焦虑与抑郁症、失眠以及冠状动脉疾病存在显着的正向遗传相关性，这反映了流行病学研究的结果。我们的结论是，常见的遗传变异在焦虑的遗传结构中占很大比例。
更新日期：2019-11-21
中文翻译：
常见遗传变异在焦虑症中的主要作用。
焦虑症是常见、复杂的精神疾病，双胞胎遗传率为 30-60%。我们对终生焦虑症进行了全基因组关联研究（ncase = 25 453，ncontrol = 58 113），并对当前焦虑症状进行了额外分析（ncase = 19 012，ncontrol = 58 113）。终身焦虑症的责任量表常见变异遗传力估计为 26%，当前焦虑症状的责任量表常见变异遗传力估计为 31%。鉴定出五个新的全基因组重要位点，包括 9 号染色体上的一个基因间区域，该区域先前与神经质有关，以及一个与 BDNF 受体基因 NTRK2 重叠的位点。焦虑与抑郁症、失眠以及冠状动脉疾病存在显着的正向遗传相关性，这反映了流行病学研究的结果。我们的结论是，常见的遗传变异在焦虑的遗传结构中占很大比例。
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