Five new matrine-type alkaloid dimers, alopecuroides A-E, were isolated from the aerial parts of Sophora alopecuroides. Alopecuroides A and B represent the first dimeric matrine-type alkaloids possessing a cyano group and an epoxy moiety. Alopecuroides C and D are dimeric matrine-type alkaloids connected via C-2-C-9' and C-10-C-3' bonds, respectively. The chemical structures of alopecuroides A-E were elucidated by spectroscopic methods combined with single-crystal X-ray diffraction analysis. The anti-inflammatory effects of alopecuroides A-E were evaluated, and alopecuroide B exhibited the most significant activity, better than that of matrine, the representative compound from S. alopecuroides.

中文翻译：

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Alopecuroides AE，苦参碱生物碱的苦参碱型生物碱二聚体。

从槐豆苦参碱的地上部分中分离出五个新的苦参碱型生物碱二聚体，苦参碱AE。类胡萝卜素A和B代表具有氰基和环氧基的第一类二聚苦参碱型生物碱。类胡萝卜素C和D是分别通过C-2-C-9'和C-10-C-3'键连接的二聚苦参碱型生物碱。结合光谱学方法结合单晶X射线衍射分析，阐明了类胡萝卜素AE的化学结构。评估了苦杏仁苷AE的抗炎作用，并且苦杏仁苷B表现出最显着的活性，比苦参碱中的代表性化合物苦参碱更好。