Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages.,Journal of Natural Products

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Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2019-11-20 , DOI: 10.1021/acs.jnatprod.9b00697
Young H Seo _{1,

2} , Shin-Young Kang , Ji-Sun Shin , Seung M Ryu ₁ , A Y Lee ₁ , Goya Choi ₁ , Byeong C Moon ₁ , Dae-Sik Jang , Sang H Shim ₃ , Dongho Lee ₄ , Kyung-Tae Lee , Jun Lee _{1,

2}

Affiliation

A new flavone glucoside, acacetin-7-O-(3″-O-acetyl-6″-O-malonyl)-β-d-glucopyranoside (1), two new phenolic glucosides, (3R,7R)-tuberonic acid-12-O-[6'-O-(E)-feruloyl]-β-d-glucopyranoside (14) and salicylic acid-2-O-[6'-O-(E)-feruloyl]-β-d-glucopyranoside (15), and two new phenylpropanoid glucosides, chavicol-1-O-(6'-O-methylmalonyl)-β-d-glucopyranoside (17) and chavicol-1-O-(6'-O-acetyl)-β-d-glucopyranoside(18), as well as 26 known compounds, 2-13, 16, and 19-31, were isolated from the aerial parts of Agastache rugose. The structures of the new compounds were established by spectroscopic/spectrometric methods such as HRESIMS, NMR, and ECD. The anti-inflammatory effect of the isolated compounds was evaluated by measuring their inhibitory activities on prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. New compounds 1, 15, 17, and 18 inhibited LPS-induced PGE2 production with IC50 values of 16.8 ± 0.8, 33.9 ± 4.8, 14.3 ± 2.1, and 48.8 ± 4.4 μM, respectively. Compounds 5, 7, 9-11, 13, 19, 20, 22, and 27-30 showed potent inhibitory activities with IC50 values of 1.7-8.4 μM.

中文翻译：

皱叶香菇地上部分的化学成分及其对脂多糖处理的RAW 264.7巨噬细胞中前列腺素E2产生的抑制活性。

一种新的黄酮葡萄糖苷，醋氨乙酸7-O-（3“ -O-乙酰基-6” -O-丙二酰基）-β-d-吡喃葡萄糖苷（1），两种新的酚类葡萄糖苷，（3R，7R）-胡椒酸- 12-O- [6'-O-（E）-阿魏酰基]-β-d-吡喃葡萄糖苷（14）和水杨酸-2-O- [6'-O-（E）-阿魏酰基]-β-d-吡喃葡萄糖苷（15）和两种新的苯基丙烷类糖苷，chavicol-1-O-（6'-O-甲基丙二酰基）-β-d-吡喃葡萄糖苷（17）和chavicol-1-O-（6'-O-乙酰基）-从Agastache rugose的地上部分中分离出了β-d-吡喃葡萄糖苷（18）以及26种已知化合物2-13、16和19-31。通过光谱/光谱方法，例如HRESIMS，NMR和ECD，确定了新化合物的结构。通过测量其对脂多糖（LPS）处理的RAW 264.7巨噬细胞中前列腺素E2（PGE2）的抑制活性，评估了分离的化合物的抗炎作用。新化合物1、15、17和18抑制LPS诱导的PGE2产生，IC50值分别为16.8±0.8、33.9±4.8、14.3±2.1和48.8±4.4μM。化合物5、7、9-11、13、19、20、22和27-30显示出有效的抑制活性，IC50值为1.7-8.4μM。

更新日期：2019-11-21

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