INTRODUCTION Previous studies on Parkinson's disease (PD) have shown that memory complaints and fatigue co-occur since premotor stages of disease, but whether Subjective Memory Decline (SMD, defined as memory complaints with normal objective cognitive performance) and fatigue were associated in PD has not been explored yet. METHODS One-hundred PD patients underwent measures of memory complaints (Multifactorial Memory Questionnaire, MMQ), neuropsychological test (Parkinson's Disease-Cognitive Rating Scale), and assessment of behavioural symptoms. Fatigue was diagnosed according to current diagnostic criteria. Mann-Whitney test or Pearson chi-square test were used to compare fatigued and nonfatigued patients for prevalence of SMD and for demographic, clinical, and behavioural features, memory complaint, and objective cognitive measures. The confounding effect of sample's features on results was controlled by logistic regression and Quade's rank analysis. RESULTS Twenty-three patients were diagnosed as fatigued whereas 15 patients met SMD criteria. Fatigued patients showed higher levodopa equivalent daily dose and more marked behavioural symptoms than nonfatigued patients (ps< 0.01). The prevalence of SMD was higher in fatigued patients than in those nonfatigued (35% vs 9%, p < 0.01). After controlling for confounds, the patients with fatigue had an odds ratio for SMD 5.97 [CI 95%, 1.18-30.03] times higher and presented significantly lower scores on Contentment subscales of MMQ (p < 0.01) than those without fatigue. CONCLUSION Fatigue in PD is associated with SMD mainly characterized by less contentment with one's own memory ability. These findings suggest possible shared pathogenic mechanisms underlying these two nonmotor manifestations and foster to identify potential phenotypes of patients requiring multistrategic therapeutic approaches.

中文翻译：

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有或没有疲劳的帕金森氏病患者的主观记忆力下降。

引言先前有关帕金森氏病（PD）的研究表明，自疾病运动前期以来，记忆障碍和疲劳并发，但PD是否与主观记忆衰退（SMD，定义为具有正常客观认知表现的记忆障碍）和疲劳相关尚未探索。方法一百名PD患者进行了记忆力抱怨（多因素记忆问卷，MMQ），神经心理测验（帕金森氏病认知等级量表）和行为症状评估。根据当前的诊断标准诊断出疲劳。使用Mann-Whitney检验或Pearson卡方检验来比较疲劳和未疲劳患者的SMD患病率，人口统计学，临床和行为特征，记忆障碍和客观认知指标。样本特征对结果的混杂影响由逻辑回归和Quade秩分析控制。结果23例患者被诊断为疲倦，而15例符合SMD标准。与未疲劳的患者相比，疲劳的患者表现出更高的左旋多巴当量日剂量和更明显的行为症状（ps <0.01）。疲劳患者的SMD患病率高于未疲劳患者（35％vs 9％，p <0.01）。在控制了混杂因素之后，疲劳患者的SMD比值比高出5.97 [CI 95％，1.18-30.03]倍，并且在MMQ知足量表上的得分明显低于无疲劳患者（p <0.01）。结论PD中的疲劳与SMD有关，其主要特征是对自己的记忆能力的满足程度较低。