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Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi003-A) from a Wilson's disease patient harboring a homozygous R778L mutation in ATP7B gene.
Stem Cell Research ( IF 1.2 ) Pub Date : 2019-11-21 , DOI: 10.1016/j.scr.2019.101664 Jiwei Zhang 1 , Liting Wei 2 , Dingbang Chen 3 , Li Feng 3 , Chao Wu 3 , Rui Wang 4 , Xunhua Li 3
中文翻译：
从具有ATP7B基因纯合子R778L突变的威尔逊病患者中产生无整合诱导多能干细胞（iPSC）系（ZZUNEUi003-A）。
更新日期：2019-11-21
Stem Cell Research ( IF 1.2 ) Pub Date : 2019-11-21 , DOI: 10.1016/j.scr.2019.101664 Jiwei Zhang 1 , Liting Wei 2 , Dingbang Chen 3 , Li Feng 3 , Chao Wu 3 , Rui Wang 4 , Xunhua Li 3
Affiliation
Human IPSC Line, ZZUNEUi003-A, was generated from a 32-year-old male patient with Wilson's Disease carrying a homozygous R778L mutation in ATP7B gene, using non-integrative reprogramming method. This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype.
中文翻译：
从具有ATP7B基因纯合子R778L突变的威尔逊病患者中产生无整合诱导多能干细胞（iPSC）系（ZZUNEUi003-A）。
人类IPSC系ZZUNEUi003-A，是使用非整合重编程方法从32岁的威尔森氏病男性患者中产生的，该患者在ATP7B基因中带有纯合R778L突变。该细胞系在体外和体内均显示多能性，并具有正常的核型。
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