The cerebrospinal fluid (CSF) is a waterly, colorless fluid contained within the brain ventricles and the cranial and spinal subarachnoid spaces. CSF physiological functions range from hydromechanical protection of the central nervous system (CNS) to CNS modulation of developmental processes and regulation of interstitial fluid homeostasis. Optic nerve (ON) is surrounded by CSF circulating in the subarachnoid spaces and is exposed to both CSF (CSFP) and intra ocular (IOP) pressures, which converge at the lamina cribrosa (LC) as two opposite forces. The trans-lamina cribrosa pressure gradient (TLPG) is defined as IOP - CSFP and its alterations (due either to an elevation in IOP or a reduction in ICP) could result in structural damaging of the ON, including glaucomatous changes. The purpose of this review is to update the readers on the CSF contribution in controlling the functions/dysfunctions of ON by regulating homeostasis at LC. We also highlight emerging parallelisms regarding the expression of cilia-related genes in the regulation of common functions of body fluids in both brain and eye structures.

中文翻译：

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在压力下：脑脊液对眼睛的生理动态平衡有贡献。

脑脊液（CSF）是一种含水的无色液体，包含在脑室以及颅和脊髓蛛网膜下腔中。脑脊液的生理功能范围从中枢神经系统（CNS）的水力机械保护到发育过程的CNS调节和间质液稳态的调节。视神经（ON）被蛛网膜下腔中循环的CSF所包围，并且暴露于CSF（CSFP）和眼内（IOP）压力下，它们以两个相反的力汇聚在筛板（LC）上。跨层筛网压力梯度（TLPG）定义为IOP-CSFP，其变化（由于IOP升高或ICP降低）可能导致ON的结构损伤，包括青光眼改变。这篇综述的目的是通过调节LC的稳态来向读者介绍CSF在控制ON的功能/功能障碍方面的贡献。我们还强调了新兴的关于纤毛相关基因在调节脑和眼结构体液的共同功能中的表达的平行性。