The cytokine TNF is thought to play a major role in the immunopathogenesis of ulcerative colitis, and anti-TNF antibodies are considered as cornerstones of clinical therapy. Two clinical trials published in The New England Journal of Medicine now challenge this paradigm and suggest new avenues for research.

中文翻译：

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针对溃疡性结肠炎的免疫细胞接线。

细胞因子TNF被认为在溃疡性结肠炎的免疫发病机理中起主要作用，并且抗TNF抗体被认为是临床治疗的基石。现在，《新英格兰医学杂志》上发表的两项临床试验对这一范例提出了挑战，并提出了新的研究途径。