Amino acids (AAs), which contain various functional groups including α-amino group, α-carboxyl group, and certain specific side-chains, exhibit a wide range of chemical properties. The derivatization of these functional groups of AAs via biocatalysis represents a sustainable approach for producing various chemicals, such as α-keto acids, α-hydroxyl acids, non-proteinogenic AAs, amines, peptides, higher alcohols, and phenylpropanoids, that are valuable in the pharmaceutical, chemical synthesis, cosmetic, and food industries. Here, we review recent advances in the derivatization of AAs to describe the design of derivatization reactions, how to overcome technical bottlenecks, and the potential range of chemicals that may be obtained. Furthermore, we highlight future prospects and address the challenges that remain in the derivatization of AAs for the production of fine chemicals.

包含各种功能基团（包括α-氨基，α-羧基和某些特定侧链）的氨基酸（AAs）具有广泛的化学性质。通过生物催化衍生化这些AA官能团代表了一种可持续的方法来生产各种化学物质，例如α-酮酸，α-羟基酸，非蛋白质AA，胺，肽，高级醇和苯基丙烷，这些在制药，化学合成，化妆品和食品工业。在这里，我们回顾了AA衍生化的最新进展，以描述衍生化反应的设计，如何克服技术瓶颈以及可能获得的化学物质范围。此外，