As an emerging novel drug carrier, nanoparticles provide a promising way for effective treatment of parasitic diseases by overcoming the shortcomings of low bioavailability, poor cellular permeability, nonspecific distribution and rapid elimination of antiparasitic drugs from the body. In recent years, some kinds of ideal nanocarriers have been developed for antiparasitic drug delivery. In this review, the progress of the enhanced antiparasitic effects of different nanoparticles payload and their influencing factors were firstly summarized. Secondly, the transport and disposition process in the body were reviewed. Finally, the challenges and prospects of nanoparticles for antiparasitic drug delivery were proposed. This review will help scholars to understand the development trend of nanoparticles in the treatment of parasitic diseases and explore strategies in the development of more efficient nanocarriers to overcome the difficulty in the treatment of parasite infections in the future.

中文翻译：

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用于抗寄生虫药物输送的纳米颗粒。


纳米颗粒作为一种新兴的新型药物载体，克服了抗寄生虫药物生物利用度低、细胞渗透性差、非特异性分布和快速从体内消除的缺点，为有效治疗寄生虫病提供了一种有前途的途径。近年来，已经开发了一些用于抗寄生虫药物递送的理想纳米载体。本文首先总结了不同纳米颗粒有效负载增强抗寄生虫作用的进展及其影响因素。其次，回顾了体内的运输和处置过程。最后，提出了纳米颗粒用于抗寄生虫药物递送的挑战和前景。该综述将有助于学者们了解纳米粒子在寄生虫疾病治疗中的发展趋势，并探索开发更高效的纳米载体的策略，以克服未来寄生虫感染治疗的困难。