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CIDE family proteins control lipid homeostasis and the development of metabolic diseases.
Traffic ( IF 3.6 ) Pub Date : 2020-01-01 , DOI: 10.1111/tra.12717 Feng-Jung Chen 1 , Yesheng Yin 1 , Boon Tin Chua 1 , Peng Li 2
Traffic ( IF 3.6 ) Pub Date : 2020-01-01 , DOI: 10.1111/tra.12717 Feng-Jung Chen 1 , Yesheng Yin 1 , Boon Tin Chua 1 , Peng Li 2
Affiliation
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Dysregulation of lipid homeostasis leads to the development of metabolic disorders including obesity, diabetes, cardiovascular disease and cancer. Lipid droplets (LDs) are subcellular organelles vital in the maintenance of lipid homeostasis by coordinating lipid synthesis, lipid storage, lipid secretion and lipolysis. Under fed condition, free fatty acids (FFAs) are remodeled and esterified into neutral lipids by lipogenesis and stored in the LDs. The lipid storage capacity of LDs is controlled by its growth via local lipid synthesis or by LD fusion. During fasting, neutral lipids are hydrolyzed by lipolysis, released as FFAs and secreted to meet energy demand. Cell death-inducing DNA fragmentation factor alpha (DFFA)-like effector (CIDE) family proteins composed of Cidea, Cideb and Cidec/Fsp27 are ER- and LD-associated proteins and have emerged as important regulators of lipid homeostasis. Notably, when localized on the LDs, CIDE proteins enrich at the LD-LD contact sites (LDCSs) and control LD fusion and growth. Here, we summarize these recent advances made on the role of CIDE proteins in the regulation of lipid metabolism with a particular focus on the molecular mechanisms underlying CIDE-mediated LD fusion and growth.
中文翻译：
CIDE家族蛋白控制脂质稳态和代谢性疾病的发展。
脂质稳态的失调导致代谢紊乱的发展，包括肥胖，糖尿病，心血管疾病和癌症。脂质滴（LDs）是通过协调脂质合成，脂质存储，脂质分泌和脂解作用而对维持脂质体内稳态至关重要的亚细胞器。在进食条件下，游离脂肪酸（FFA）被重塑并通过脂肪生成酯化为中性脂质，并储存在LDs中。LD的脂质存储能力通过其通过局部脂质合成或LD融合的生长来控制。在禁食期间，中性脂质通过脂解作用水解，以FFA形式释放并分泌以满足能量需求。由Cidea组成的诱导细胞死亡的DNA片段化因子α（DFFA）样效应物（CIDE）家族蛋白，Cideb和Cidec / Fsp27是与ER和LD相关的蛋白，已成为脂质体内稳态的重要调节剂。值得注意的是，当CIDE蛋白位于LDs上时，它会在LD-LD接触位点（LDCSs）富集并控制LD融合和生长。在这里，我们总结了有关CIDE蛋白在脂质代谢调节中的作用的最新进展，特别关注了CIDE介导的LD融合和生长的分子机制。
更新日期：2019-12-19
中文翻译：
CIDE家族蛋白控制脂质稳态和代谢性疾病的发展。
脂质稳态的失调导致代谢紊乱的发展，包括肥胖，糖尿病，心血管疾病和癌症。脂质滴（LDs）是通过协调脂质合成，脂质存储，脂质分泌和脂解作用而对维持脂质体内稳态至关重要的亚细胞器。在进食条件下，游离脂肪酸（FFA）被重塑并通过脂肪生成酯化为中性脂质，并储存在LDs中。LD的脂质存储能力通过其通过局部脂质合成或LD融合的生长来控制。在禁食期间，中性脂质通过脂解作用水解，以FFA形式释放并分泌以满足能量需求。由Cidea组成的诱导细胞死亡的DNA片段化因子α（DFFA）样效应物（CIDE）家族蛋白，Cideb和Cidec / Fsp27是与ER和LD相关的蛋白，已成为脂质体内稳态的重要调节剂。值得注意的是，当CIDE蛋白位于LDs上时，它会在LD-LD接触位点（LDCSs）富集并控制LD融合和生长。在这里，我们总结了有关CIDE蛋白在脂质代谢调节中的作用的最新进展，特别关注了CIDE介导的LD融合和生长的分子机制。
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