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Glioma progression through synaptic activity.
Nature Reviews Neurology ( IF 28.2 ) Pub Date : 2020-01-01 , DOI: 10.1038/s41582-019-0290-1
Mary Jane Lim-Fat 1 , Patrick Y Wen 1, 2, 3
Affiliation  

Two new studies show that gliomas can manipulate normal elements of neuronal development and plasticity to create neuron–glia synapses, activation of which leads to glioma proliferation. Interventions that target the AMPA receptor could slow down tumour growth by altering this synaptic transmission.

中文翻译:

神经胶质瘤通过突触活动发展。

两项新的研究表明,神经胶质瘤可以操纵神经元发育和可塑性的正常元素来产生神经元-神经胶质突触,其激活导致神经胶质瘤的增殖。针对AMPA受体的干预措施可以通过改变这种突触传递来减慢肿瘤的生长。
更新日期:2019-11-20
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