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Generation of a NKX2.1 - p63 double transgenic knock-in reporter cell line from human induced pluripotent stem cells (MHHi006-A-4).
Stem Cell Research ( IF 1.2 ) Pub Date : 2019-11-19 , DOI: 10.1016/j.scr.2019.101659 Nora Drick 1 , Anais Sahabian 2 , Praeploy Pongpamorn 2 , Sylvia Merkert 2 , Gudrun Göhring 3 , Tobias Welte 4 , Ulrich Martin 2 , Ruth Olmer 2
中文翻译：
从人诱导的多能干细胞（MHHi006-A-4）生成NKX2.1-p63双转基因敲入报告基因细胞系。
更新日期：2019-11-19
Stem Cell Research ( IF 1.2 ) Pub Date : 2019-11-19 , DOI: 10.1016/j.scr.2019.101659 Nora Drick 1 , Anais Sahabian 2 , Praeploy Pongpamorn 2 , Sylvia Merkert 2 , Gudrun Göhring 3 , Tobias Welte 4 , Ulrich Martin 2 , Ruth Olmer 2
Affiliation
Tumor protein p63 (p63) encodes for a transcription factor of the p53 family and is a marker for respiratory basal cells. Based on a NKX2.1 knock-in reporter cell line from human induced pluripotent stem cells (hiPSCs) (MHHi06-A-2) we established a NKX2.1/p63 double transgenic knock-in reporter cell line using TALEN technology. The reporter enables the optimization and monitoring of hiPSC differentiation towards NKX2.1/p63 double positive cells as well as enrichment for single or double positive cells.
中文翻译：
从人诱导的多能干细胞（MHHi006-A-4）生成NKX2.1-p63双转基因敲入报告基因细胞系。
肿瘤蛋白p63（p63）编码p53家族的转录因子，是呼吸基底细胞的标志物。基于人类诱导的多能干细胞（hiPSC）（MHHi06-A-2）的NKX2.1敲入报告基因细胞系，我们使用TALEN技术建立了NKX2.1 / p63双转基因敲入报告基因细胞系。报道分子能够优化和监测hiPSC向NKX2.1 / p63双阳性细胞分化的能力，以及富集单或双阳性细胞的能力。
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