Micro/Nano Technology for Next‐Generation Diagnostics,Small Methods

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Micro/Nano Technology for Next‐Generation Diagnostics
Small Methods ( IF 10.7 ) Pub Date : 2019-11-20 , DOI: 10.1002/smtd.201900506
Huan Xu ₁ , Mingxuan Gao ₁ , Xiaoqi Tang ₁ , Wenqing Zhang ₁ , Dan Luo _{2,

3} , Ming Chen _{1,

4,

5}

Affiliation

There has been a constant and urgent need to upgrade the current diagnostic technologies to the next generation by utilizing innovative advanced technologies in order to meet new challenges. Micro/nano technology, a series of methods for design and manipulation materials at the micrometer and nanometer scales, which perfectly covers the key building blocks of life including cells, organelles, proteins, nucleic acids, and other components, has unique advantages over current diagnostic methods. For the applications of micro–nano technology in next‐generation diagnostics, three categories, including microchip‐based devices, DNA nanomachines, and DNA nanomaterials, are extensively reviewed. Specifically, for the microchip‐based devices, terahertz technology and surface acoustic wave technology show their ultrasensitivity of label‐free, amplification‐free diagnosis. For the DNA nanomachines, DNA tweezers, DNA robots, and DNA walkers exhibit a great potential for diagnosis with the arbitrary structures and controllable motion behaviors. For the DNA nanomaterials, DNA aptamers, DNAzymes, and hybrid DNA nanomaterials provide sensitive biorecognition elements and versatile signal transductions, which are demonstrated as promising material candidates for the next‐generation diagnostics. Through this review, it is envisioned that micro/nano technologies will play an important role in the next‐generation diagnostics.

中文翻译：

Micro / Nano技术用于下一代诊断

一直迫切需要通过利用创新的先进技术将当前的诊断技术升级到下一代技术，以应对新的挑战。微米/纳米技术是一系列用于微米和纳米级材料的设计和处理方法，可完美涵盖生命的关键组成部分，包括细胞，细胞器，蛋白质，核酸和其他成分，与当前的诊断方法相比，具有独特的优势方法。对于微纳米技术在下一代诊断中的应用，广泛地审查了三类，包括基于微芯片的设备，DNA纳米机器和DNA纳米材料。具体地说，对于基于微芯片的设备，太赫兹技术和表面声波技术表现出了它们对无标签，无扩增诊断。对于DNA纳米机器，DNA镊子，DNA机器人和DNA Walker具有任意结构和可控制的运动行为的诊断潜力。对于DNA纳米材料，DNA适体，DNA酶和杂交DNA纳米材料提供了敏感的生物识别元件和通用的信号转导，已被证明是下一代诊断技术的有希望的候选材料。通过这次审查，可以预见，微米/纳米技术将在下一代诊断中发挥重要作用。杂交DNA纳米材料提供了灵敏的生物识别元件和通用的信号转导，已被证明是下一代诊断技术的有希望的候选材料。通过这次审查，可以预见，微米/纳米技术将在下一代诊断中发挥重要作用。杂交DNA纳米材料提供了灵敏的生物识别元件和通用的信号转导，已被证明是下一代诊断技术的有希望的候选材料。通过这次审查，可以预见，微米/纳米技术将在下一代诊断中发挥重要作用。

更新日期：2019-11-20

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