In The Lancet Diabetes & Endocrinology, Simon Griffin and colleagues report the results of a 10-year follow-up analysis of the Anglo-Danish-Dutch Study of Intensive Treatment In People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe), assessing outcomes 5 years post-intervention. The pragmatic, cluster-randomised, parallel-group trial was designed to examine effects of early intensive multifactorial treatment on cardiovascular outcomes in patients with newly diagnosed type 2 diabetes identified through screening. The primary endpoint was a composite of first cardiovascular event, including cardiovascular mortality, cardiovascular morbidity (non-fatal myocardial infarction and non-fatal stroke), revascularisation, and non-traumatic amputation. 343 general practices in Denmark, the Netherlands, and the UK were randomly assigned to routine diabetes care or intensive multifactorial treatment. Between April, 2001, and December, 2006, population-based stepwise screening programmes among people aged 40–69 years in these general practices identified 3057 patients with type 2 diabetes who agreed to participate in the trial. Less than 10% of patients had a history of myocardial infarction or stroke.

中文翻译：

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欧洲以外的地区：第一个十年及以后。

在《柳叶刀》糖尿病与内分泌学中，Simon Griffin及其同事报告了对盎格鲁-丹麦-荷兰人在初级卫生保健中筛查糖尿病患者进行强化治疗的10年随访分析结果（ADDITION-Europe），评估了5年后的结局干涉。这项实用，整群，随机分组的试验旨在检查早期强化多因素治疗对通过筛查确定的新诊断出的2型糖尿病患者的心血管结局的影响。主要终点是首次心血管事件的综合结果，包括心血管疾病的死亡率，心血管疾病的发病率（非致命性心肌梗塞和非致命性中风），血运重建和非创伤性截肢。丹麦，荷兰，和英国被随机分配到常规糖尿病护理或强化多因素治疗。在2001年4月至2006年12月之间，按照这些一般做法对40-69岁的人群进行了基于人群的逐步筛查计划，确定了3057名同意参加该试验的2型糖尿病患者。少于10％的患者有心肌梗塞或中风病史。