Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction,Toxicology Research

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Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction
Toxicology Research ( IF 2.2 ) Pub Date : 2019-11-20 , DOI: 10.1039/c9tx00240e
Yuexiang Niu ₁ , Engong Tang ₁ , Qingan Zhang ₁

Affiliation

Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO₂) towards cancer cells has been reported previously, but the specific mechanism is not fully clear. In this study, Nano-SiO₂ showed a remarkable cytotoxic effect against HCC cells, regardless of whether the cells were drug resistant or not. Further study showed that Nano-SiO₂ treatment leads to cell cycle arrest, apoptosis enhancement and necroptosis induction in the HCC cells. RNA-seq data, together with bioinformatics analysis, revealed that a series of genes involved in cancer cell death could be regulated by Nano-SiO₂, among which ZBP-1 was up-regulated the most by Nano-SiO₂ treatment. The siRNA based experiments demonstrated that ZBP-1 might play a key role in mediating Nano-SiO₂ cytotoxic functions against HCC cells. These results have evidently signified the anti-tumor potential of Nano-SiO₂ in the treatment of HCC.

中文翻译：

二氧化硅纳米颗粒通过坏死病诱导对肝癌细胞的细胞毒作用

肝细胞癌（HCC）是一种常见的癌症，它以高发病率和高死亡率影响着全世界的人们，其对当前化疗药物的耐药性已成为一个严重的问题。二氧化硅纳米颗粒（Nano-SiO ₂）对癌细胞的细胞毒性已有报道，但具体机制尚不完全清楚。在这项研究中，无论细胞是否具有耐药性，纳米SiO ₂对HCC细胞均显示出显着的细胞毒性作用。进一步的研究表明，纳米SiO ₂处理可导致HCC细胞的细胞周期停滞，细胞凋亡增强和坏死病诱导。RNA-seq数据以及生物信息学分析表明，纳米癌细胞可以调控一系列与癌细胞死亡有关的基因_{如图2所示}，其中通过纳米SiO₂处理将ZBP-1上调最多。基于siRNA的实验表明ZBP-1可能在介导针对HCC细胞的Nano-SiO₂细胞毒性功能中起关键作用。这些结果显然表明了纳米SiO₂在治疗HCC中的抗肿瘤潜力。

更新日期：2019-11-20

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